Protective Role of Berberine-Loaded Bovine Serum Albumin Nanoparticles Towards β-Cyfluthrin-Induced Cardiotoxicity in Male Rats | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 18 November 2025 PDF (2.12 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.413195.3037 | ||
| Authors | ||
| lamiaa G Wasef* 1; Abdelrhman Taher1; Rehab Mady1; Gehan A. M. Khodear2; Hazem M Shaheen1 | ||
| 11Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Damanhour, Egypt | ||
| 2Fellow of biochemistry medical technology center medical institute research Alexandria university | ||
| Abstract | ||
| β-Cyfluthrin(β-CYF), a class II Pyrethroid, is an insecticide used worldwide in agriculture, the current study was intended to explore the prospect of β-cyfluthrin to persuade oxidative stress and biochemical perturbations in cardiac tissue and the effect of Berberine (BBR) and Berberine-Loaded BSA (Bovine Serum Albumin) Nanoparticles (BNPs) in alleviating its cardiotoxicity. Male Wistar rats (n = 40) were randomly allocated into eight groups of five animals each. Group I served as the control, while Group II received berberine (BBR, 10 mg/kg) and Group III received berberine nanoparticles (BNP, 5 mg/kg). Group IV was administered β-cyfluthrin (β-CYF, 15 mg/kg BW), whereas Groups V and VI were given β-CYF (15 mg/kg) followed by BBR (10 mg/kg) or BNP (5 mg/kg), respectively. Group VII received bovine serum albumin (1 mL), and Group VIII received corn oil (1 mL). All treatments were administered once daily by oral gavage for 15 days. Upon β-cyfluthrin exposure, a significant elevation was observed in lipid peroxidation (MDA) and a reduction in the protective activities of antioxidant enzymes like Total Antioxidant Capacity (TAC) and superoxide dismutase (SOD), This was accompanied by increase cardiac biomarkers (LDH, CPK, CK-MB) in the serum. Berberine Nanoparticles and Berberine administration pointedly Significant declined the serum and tissue quantity of cardiac enzyme and oxidative stress biomarkers in β-cyfluthrin treated rats and restored heart tissue integrity. The findings indicate that oxidative stress plays a crucial role in heart damage caused by cyfluthrin, BNPs is a prevailing antioxidant, can mitigate β-cyfluthrin's negative impact on rat heart tissue. | ||
| Keywords | ||
| β-cyfluthrin; Antioxidant; Berberine nanoparticles; Oxidative stress; cardiotoxicity | ||
|
Statistics Article View: 1 |
||
