The ameliorative effect of Quercetin against cadmium chloride-induced testicular oxidative challenges in a rat model | ||
| Journal of Veterinary Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 18 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jvmr.2025.434788.1139 | ||
| Authors | ||
| esraa ramadan Bassiouny* 1; Kamel M.A. Hassanin2; Ahmed Abdel-Wahab3; Abdel-Razik H Abdel-Razik4; Hisham Ismail5 | ||
| 1biochemistry department , faculty of sciences , minia university | ||
| 2Biochemistry Department, Faculty of Veterinary Medicine, Minia University | ||
| 3Physiology Department, Faculty of Veterinary Medicine, Minia University, Minia 61519, Egypt. | ||
| 4Histology Department, Faculty of Veterinary Medicine, Beni-Suef University | ||
| 5Biochemistry Division, Chemistry Department, Faculty of Science, Minia University | ||
| Abstract | ||
| Cadmium (Cd) is regarded as one of the most prevalent heavy metals causing harm to environment. Oxidative stress was the main outcome of Cd exposure. Quercetin (Qu) is a naturally occurring antioxidant present in a wide variety of foods (broccoli and onions) and is known for its distinct antioxidant properties. The goal of the present study was to investigate protective effects of Quercetin (Qu) and its capacity to safeguard testes from oxidative stress caused by cadmium (Cd). For that reason, twenty-seven adult male rats were divided into three groups of nine rats each at random. Group 1 (Control), animals received distilled water as a vehicle. In group 2 (Cadmium chloride “CdCl2” group), animals received 5 mg CdCl2/ kg BW, while in group 3 (CdCl2+Qu), animals received 5 mg CdCl2/ kg BW plus 10 mg Qu /kg BW. All rats received their corresponding treatments by oral gavage daily for 2 months. Results illustrated that rats exposed to CdCl2 showed insignificant reduction in body weight and elevation of gonadosomatic index (GSI) compared to other groups (P>0.05). Concomitantly, CdCl2 administration led to a substantial decrease in testicular reduced glutathione (GSH) levels and a marked increase in MDA (P<0.05). However, Qu supplementation drmatically decreased testicular oxidative stress by increasing testicular GSH levels and notably lowering MDA (P<0.05). Histopathological picture of testicular tissue confirmed the beneficial effects of Qu supplementation on testicular activity. Consequently, Qu may be considered an excellent preventative measure to protect rats' testicles from oxidative insults caused by Cadmium Chloride. | ||
| Keywords | ||
| Cadmium chloride; Quercetin; oxidative stress; testes | ||
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