The Impact of CD200 and CD56 Expression on The Prognosis of Acute Myeloid Leukemia Patients at Ain Shams University Hospitals | ||
| Ain Shams Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 19 November 2025 PDF (460.88 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asmj.2025.341179.1345 | ||
| Authors | ||
| Israa Yosry Ali1; Iman Mohamed Amin1; Maha Ahmed Abdel Rady* 2 | ||
| 1Clinical Pathology Department, Faculty of Medicine Ain Shams University | ||
| 2Clinical pathology , faculty of Medicine , Ain Shams University,Cairo, Egypt | ||
| Abstract | ||
| Background: Acute myeloid leukemia (AML) is a clonal malignant disease of hematopoietic tissue which results from a block of normal differentiation of hematopoietic progenitor cells along with uncontrolled proliferation of cells of myeloid origin with maturation arrest leading to infiltration of bone marrow and other tissues by myeloblasts. It escapes from immunosurveillance by induction of immunosuppression through expression of specific cell surface molecules with immune modulatory function. Novel immune-directed therapeutic approaches form a major focus of current and clinical research. Objective: To evaluate the expression levels of CD200 and CD56 in newly diagnosed acute myeloid leukemia (AML) patients (classified according to FAB classification) and assess the prognostic significance of their positive expression in AML cases. Methods: This Cohort study was conducted at Ain Shams University Hospitals, on 51 newly diagnosed adult AML patients attending the Hematology Oncology Unit of Ain-Shams University Hospitals from February 2022 until June 2023. Results: The CD200+ expression was reported in 74.5% of patients while 9.8% of patients showed CD56+ expression. The M1-M2 were found to be the most common FAB subtypes. CD200+ was higher among female patients (p= 0.045). On the other hand, CD56+ patients were younger in comparison to CD56- patients (p= 0.002). Total death was higher among CD200+ patients than CD200- patients (p= 0.037). Conclusion: Our study indicates that CD200 expression is linked to a higher mortality rate, suggesting a negative effect on survival, whereas CD56 expression does not show a significant association with mortality. | ||
| Keywords | ||
| FAB classification; immune evasion; immunomodulatory markers; survival | ||
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