Role of Diffusion MRI, Volumetry and Tumor Necrosis in the Assessment of the Response of Breast Cancer after Neoadjuvant Systemic Therapy (NAST) | ||
| Ain Shams Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 19 November 2025 PDF (573.5 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asmj.2025.379801.1441 | ||
| Authors | ||
| Hazem Ibrahim Korashi1; Nancy Tarek Elwasly2; Kamal Mamdouh Kamal3; Basant Mohamed Raief Mosaad* 4 | ||
| 1Department of Radiodiagnosis, Faculty of medicine, Ain shams University, Cairo, Egypt | ||
| 2Department of oncology, Faculty of Medicine , Ain Shams University , Cairo, Egypt | ||
| 3Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||
| 4Department of Radiodiagnosis, Faculty of medicine, Ain shams University, Cairo, Egypt | ||
| Abstract | ||
| Background: To study the role of diffusion MRI, volumetry, tumor necrosis in the assessment of the response of breast cancer after neoadjuvant systemic therapy (NAST) Results: Only 88 patients completed the study, with a mean age of 56 years old. Among these patients, 72 were categorized as respondents and 16 as non-respondents. The signal criteria changes of DCE, DWI, and ADC values, as well as the tumor volume, were significant among the respondents with a significant p value<0.001. No significant association between tumor necrosis volume and complete pathological response (p value=0.96). Conclusion: The combination of DCE, volumetry, and diffusion as well as the ADC changes increase the ability and power of the MRI examination as a tool for assessment of the breast malignant neoplasms after NAST. No significant associations between the necrosis of breast cancer lesion by pre-therapy MRI and the collective image characteristics regarding the tumor necrosis. | ||
| Keywords | ||
| ADC; breast cancer; diffusion-weighted images (DWI); dynamic contrast enhancement (DCE); Neoadjuvant systemic therapy (NAST) | ||
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