Prevalence of Thyroid Dysfunction in Patients with Chronic Kidney Disease | ||
| Ain Shams Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 19 November 2025 PDF (374.28 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asmj.2025.363914.1403 | ||
| Authors | ||
| Ali Ragab Hassan Awad* 1; Samy Abdelkader Khodeir2; Ghada Abdelmoumen Soliman3; Amal Abdelmoniem Selim2 | ||
| 1Internal Medicine Department, Tanta University, Faculty of Medicine, Tanta, Egypt | ||
| 2Internal Medicine Department, Tanta University, Faculty of Medicine, Tanta, Egypt | ||
| 3Clinical Pathology Department, Tanta University, Faculty of Medicine, Tanta, Egypt | ||
| Abstract | ||
| Background: Chronic renal failure can affect thyroid function through various mechanisms, including reduced levels of circulating thyroid hormones, increased iodine retention within the thyroid glands, altered peripheral hormone metabolism, impaired transport protein binding, and possibly decreased thyroid hormone concentrations in tissue. Aim of the Study: The study aimed to assess the prevalence of thyroid dysfunction at various stages of chronic kidney disease (CKD) and to highlight the significance of screening for thyroid dysfunction in patients with CKD. Methods: This cross-sectional study involved 202 patients with clinical criteria of CKD (estimated glomerular filtration rate <60 ml/min/1.73m²). Patients were categorized into two groups: a dialysis-dependent group of patients (n = 92) and a non-dialysis-dependent group of patients (n = 110). A thyroid ultrasound examination was performed on each patient. Results: There was a negative correlation between blood urea nitrogen (BUN) and thyroid stimulating hormone (TSH) in the non-dialysis group. At the same time, there was no correlation between [BUN and TSH], [creatinine and (TSH, free triiodothyronine (T3) and thyroxine (T4)]in the dialysis group. In the dialysis group, there was a positive association between [parathyroid hormone (PTH) and BUN] and [hemoglobin level and Free T4]. In both the dialysis and non-dialysis groups, there was a negative connection between PTH and calcium levels (P≤ 0.05). Conclusions: The development of CKD is strongly associated with thyroid dysfunction, especially hypothyroidism. | ||
| Keywords | ||
| Chronic kidney disease; thyroid dysfunction; uremia; thyroid function | ||
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