Metabolic Syndrome in Colorectal Cancer Patients | ||
| Ain Shams Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 19 November 2025 PDF (408.54 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/asmj.2025.373916.1438 | ||
| Authors | ||
| Nesma Ali Ibrahim* 1; Fatma Mohamed Abouelkasem2; Yousry Wasef Nada3; Abdallah Rady Elkordy4 | ||
| 1Department of internal medicine, faculty of medicine, Ain Shams University, Cairo, Egypt | ||
| 2Medical Oncology Department, National Cancer Institute, Cairo University, Egypt. | ||
| 3Medical Oncology Department, Maadi Armed Forces Medical Complex, Military Medical Academy. | ||
| 4Medical Oncology Department, Maadi Armed Forces Medical Complex, Armed Forces College of Medicine (AFCM). | ||
| Abstract | ||
| Background: There is epidemiological evidence indicating the relation between metabolic syndrome (MetS) and colorectal cancer (CRC). Objective: To detect the presence of MetS in newly diagnosed CRC patients and to assess the association of various components of MetS and CRC. Methods: A cross-sectional study involved patients who had recently diagnosed to have CRC. Patient demographic data was gathered, and measurements were taken for the components of metabolic syndrome, including fasting plasma glucose (FPG), triglycerides (TG), high-density lipoprotein (HDL), blood pressure, and waist circumference (WC) for all participants. Results: Seventy two participants who were recently diagnosed to have CRC, among them, 30 patients (40.67%) had MetS. The degree of differentiation was significantly different between patients with MetS and those without MetS; poor differentiation was significantly higher in patients with MetS compared to those without MetS (p- value = 0.001), while moderate differentiation was significantly lower in patients with MetS compared to those without MetS (p-value = 0.02). While, there was no significant difference between both groups regarding lymph node metastasis, distant metastasis and stage. The multivariate logistic regression analysis revealed that WC, total cholesterol, TG, HDL, FPG and HbA1c were associated significantly with CRC. Conclusion: The occurrence of MetS among CRC patients is relatively high, which indicates a need for additional research to clarify the relationship between MetS and CRC development. If this link be validated, individuals with MetS have to be included in CRC screening initiatives. | ||
| Keywords | ||
| Association; colorectal cancer; metabolic syndrome | ||
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