Infectious triggers of neurodegeneration: A focus on bacterial mechanisms of brain injury | ||
| Microbes and Infectious Diseases | ||
| Articles in Press, Accepted Manuscript, Available Online from 20 November 2025 | ||
| Document Type: Systematic review or meta-analysis | ||
| DOI: 10.21608/mid.2025.404814.3024 | ||
| Authors | ||
| Rahul Kumar* 1; Varsha Mittal2; Ayushi Kimothi1; Neha Kamboj1; Ayushi Jaiswal1 | ||
| 1Department of Microbiology, Graphic Era (Deemed to be University), 566/6, Clement Town, Dehradun-248002, Uttarakhand, India | ||
| 2Department of CSE Graphic Era (Deemed to be University), 566/6, Clement Town, Dehradun-248002, Uttarakhand, India | ||
| Abstract | ||
| Background: Neurodegenerative disorders, such as Alzheimer's and Parkinson's, are increasingly becoming global health issues classically associated with genetic and lifestyle determinants. However, recent studies have underscored the significant role that bacterial infections play in the development and progression of these disorder. Major pathogens such as Porphyromonas gingivalis, Chlamydia pneumoniae, and spirochetes have been identified within the Alzheimer's with meta-analyses indicating a more than 10-fold elevated risk of disease from such infections. Technical advancements in aare increasingly allowing the deciphering of complex interactions. Multi-omics analysis powered by AI and ML-based models for modeling and analysis from neuroimaging and clinical data allows early diagnosis, biomarker identification, and personalized treatment options. Collectively, these technologies have the potential to revolutionize the diagnosis, prevention, and treatment of bacteria-related neurodegenerative diseases. This review explores microbial infections interactions to neurodegenerative disorders and their detection strategy. | ||
| Keywords | ||
| Bacterial pathogens; Blood brain barrier; Infectious triggers; Gut brain axis; neurodegenerative diseases | ||
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