Protective and Curative Effect of Lemon Balm Leaves (Melissa Officinalis L.) In A Rat Model Of CCL4 - Induced Hepatotoxicity | ||
| مجلة دراسات وبحوث التربية النوعية | ||
| Volume 11, Issue 4 - Serial Number 30, October 2025, Pages 1019-1033 PDF (1.42 M) | ||
| Document Type: المقالة الأصلية | ||
| DOI: 10.21608/jsezu.2025.466631 | ||
| Author | ||
| Sara Atef Ali Mahmoud | ||
| Applied college – Nutrtion Department - Al-Baha University- Kingdom of Saudi Arabia | ||
| Abstract | ||
| The goal of this research was to assess the impact of lemon balm at dose 10g/kg and 20 g/kg daily on the hepatotoxicity of man albino rats. The trial has been done on 42-man albino rats. The rats have been classified into 7 main groups, involving omit it protective and curative groups, after being fed the optimal diet for one week (six rats omit it each). Therapeutic teams: Group 1 was given a basal food as the negative control group. Group two was a positive control group that received a basal diet along with three weekly injections of carbon tetrachloride (CCl4) (one milligram per kilogram body wt.) to cause hepatotoxicity. The group (2) plus 10g/kg lemon balm daily by gastric tube for next 8 weeks was fed to the third group. Group (4) was fed the same as group (2) plus 20g/kg lemon balm daily by gastric tube for next 8 weeks. Defense Organizations Group (1)'s curative group and negative control group were similar. After eight weeks, the group (5) positive control group was given a basal diet plus a ccl4 injection (1 mg/kg body weight). The group (5) plus 10g/kg lemon balm daily by gastric tube for next 8 weeks was fed to the group (6). The group (7) received the group (5) plus 20g/kg lemon balm daily by gastric tube for next 8 weeks. The investigation documented that providing hepatotoxicity lemon balm at 10g/kg and 20% in the curative add and protective groups increased of feed intake, body weight gain, and feed efficiency ratio. Our results could add as follows: diets enriched with 10g/kg and 20g/kg lemon balm improved blood lipid concentrations and reduced kidney and liver function risks. | ||
| Keywords | ||
| Hepatotoxicity; lemon balm - Liver function - Kidney function - antioxidant | ||
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