Inflammatory Markers in Poly Cystic Syndrome | ||
| Al-Azhar University Journal of Medical and Virus Researches and Studies | ||
| Volume 7, Issue 2, August 2025, Pages 118-129 PDF (419.12 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aujv.2025.466634 | ||
| Abstract | ||
| Polycystic ovary syndrome (PCOS) is a public and complex endocrine illness of female in their procreative ages. Females with PCOS take cluster of cardiac hazard features, such as overweightness, dyslipidemia, reduced glucose tolerance and high blood pressure. They are at high risk of emerging coronary heart disease (CHD). Fatty tissue theatres a dominant part in the association between cytokines and insulin resistance. The appearance of TNF-α and TNFR2 in fatty tissues is amplified in overweightness. TNF-α appearance associates with catalogs of insulin resistance and reductions with weightiness loss in equivalent with the development in insulin sensitivity. to evaluate the circulating concentrations of hs CRP, IL-6, IL-18 and TNF-α as serum markers of inflammation in a group of PCOS compared with healthy controls. This study included 120 patients who were carefully chosen from the case clinic of obstetrics and gynecology at Al-Hussein Hospital. Healthy Volunteers of age group 18- 45 years females with standard reproductive cycle were involved and those who current with history of inflammatory medications or illnesses are omitted. Patients who have high blood pressure or diabetes are also omitted from health control. The patients were alienated into three groups: Group 1: Healthy control, Group 2: Recently detected PCOS and Group 3: Previously on management for PCOS. There was statistically significant change between groups I with II and groups II with III regarding weight and BMI. There was statistically significant difference between groups I with II and I with III. There was statistically significant difference between three studied groups regarding LH, FSH and TSH. There was statistically significant difference between groups I with III and II with III. There was statistically significant difference between three studied groups regarding TNF-alpha. There was statistically significant difference between groups I with II and groups I with III. There was statistically significant difference between three groups studied regarding Hs-CRP. There was statistically significant difference between three studied groups regarding IL-18. There was significant negative correlation between IL-18 with IL-6, WHR (waist/hip ratio), FSH, and progesterone while there was significant positive correlation with Hs-CRP, WC (waist circumference), HC (hip circumference), LH and progesterone. The elevated plasma levels of TNF- α, IL-6 Hs-CRP and IL-18 among PCOS women reflects a state of chronic inflammation with potential implication for insulin resistance, independent of obesity. | ||
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