Peripapillary perfusion changes influenced by intravitreal Ranibizumab in diabetic macular edema patients– an OCT angiography study
Awwad, M., Fathy, M., Saeed, A., Mohamed, O. (2025). Peripapillary perfusion changes influenced by intravitreal Ranibizumab in diabetic macular edema patients– an OCT angiography study. EKB Journal Management System, (), -. doi: 10.21608/bmfj.2025.422660.2659
Mohamed A. Awwad; Magdy A. Fathy; Ahmed M. Saeed; Ola A. Mohamed. "Peripapillary perfusion changes influenced by intravitreal Ranibizumab in diabetic macular edema patients– an OCT angiography study". EKB Journal Management System, , , 2025, -. doi: 10.21608/bmfj.2025.422660.2659
Awwad, M., Fathy, M., Saeed, A., Mohamed, O. (2025). 'Peripapillary perfusion changes influenced by intravitreal Ranibizumab in diabetic macular edema patients– an OCT angiography study', EKB Journal Management System, (), pp. -. doi: 10.21608/bmfj.2025.422660.2659
Awwad, M., Fathy, M., Saeed, A., Mohamed, O. Peripapillary perfusion changes influenced by intravitreal Ranibizumab in diabetic macular edema patients– an OCT angiography study. EKB Journal Management System, 2025; (): -. doi: 10.21608/bmfj.2025.422660.2659

Peripapillary perfusion changes influenced by intravitreal Ranibizumab in diabetic macular edema patients– an OCT angiography study

Benha Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 20 November 2025    PDF (720.95 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2025.422660.2659
Authors
Mohamed A. Awwad1; Magdy A. Fathy1; Ahmed M. Saeed1; Ola A. Mohamed* 2
1Department of Ophthalmology, Faculty of Medicine – Benha University
2M.B.B.Ch., of Ophthalmology, Faculty of Medicine – Benha University
Abstract
Background: Optical coherence tomography angiography (OCTA) is a method for noninvasively visualizing the vascular function of Optic Nerve Head (ONH) at the capillary level. A significant reduce in Optic Nerve Head vascular function has been found in a rat model of high intraocular pressure utilizing optical coherence tomography angiography. Aim: To assess the influence of intravitreal injection of antiVEGF Ranibizumab (lucentis) on peripapillary capillary perfusion in diabetic macular edema patients by OCTA. Patients and methods: A prospective cohort cross-sectional interventional research. This study was conducted in ophthalmology department and outpatient follow-up retina unit, Benha university hospital. Time of the study: from August 2023 till January 2024. Results: Superior RPC density significantly increased from 48.3 ± 6.17% to 50.8 ± 6.19% (P=0.01), and whole disc RPC density (all vessels) rose from 47.6 ± 3.77% to 55.1 ± 4.12% (P<0.001). Inferior RPC density showed no significant change (P=0.06). IOP changes were insignificant (17.3 ± 1.84 mmHg to 19.3 ± 4.74 mmHg, P=0.06). Conclusion: Intravitreal Ranibizumab significantly enhances peripapillary and whole disc perfusion in DME patients without significant IOP elevation. Long-term effects on ONH perfusion require further investigation.
Keywords
Diabetic macular edema; Ranibizumab; OCT angiography
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