Kidney function and renal resistive index in children with juvenile idiopathic arthritis | ||
| Benha Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 23 November 2025 PDF (822.03 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2025.417488.2652 | ||
| Authors | ||
| Wesam E. Afify1; Mohamed S. Sleem2; Inas M. Sweed3; Olfat G. ELsaeid4; Tasneem H. Elshony* 5 | ||
| 1Assistant Professor of Pediatrics Faculty of Medicine –Benha University | ||
| 2Professor of Pediatrics Faculty of Medicine –Benha University | ||
| 3Assistant Professor of radiodiagnosis, benha radiology- Faculty of Medicine | ||
| 4Lecturer of Rheumatology, Rehabilitation and Physical Medicine - Faculty of Medicine - Benha University | ||
| 5M.B.B.Ch. Faculty of Medicine- Benha University | ||
| Abstract | ||
| Background: Juvenile idiopathic arthritis (JIA) represented the most common chronic rheumatologic disorder in children. While joint inflammation was the primary manifestation, growing evidence indicated that extra-articular complications, particularly renal involvement, could develop early and often remain asymptomatic. Aim: To evaluate early renal functional changes in children with JIA and examine their association with disease activity and treatment regimens. Methods: This case–control investigation recruited 50 children with JIA and 50 age- and sex-matched healthy controls. All participants underwent detailed clinical and laboratory assessments. Renal evaluation included serum creatinine, estimated glomerular filtration rate (eGFR), urinary albumin excretion, and Doppler ultrasonography for measurement of the renal resistive index (RRI). Disease activity was assessed using the Juvenile Arthritis Disease Activity Score (JADAS-27). Results: Compared with controls, children with JIA showed a significant reduction in eGFR and an elevation in RRI (p < 0.05). Higher RRI values correlated with increased disease activity, were more pronounced in cases receiving biologic agents than those on methotrexate, and were associated with ANA/RF positivity, greater urinary albumin levels, and reduced eGFR. Conclusion: JIA is linked with subtle renal dysfunction that may not be evident clinically. Routine incorporation of Doppler-based RRI into follow-up protocols could aid in the early recognition and surveillance of renal involvement in affected children. | ||
| Keywords | ||
| Kidney function; renal resistive index; children; JIA: RRI | ||
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