Insecticidal Evaluation and Structure-Activity Relationship Study of Some Synthesized Urea and Thiourea Derivatives Against Spodoptera Littoralis (Boisd.)
Abdal majeed, N., El saghier, A., Gad, M., Aref, S., Abdlhamid, A. (2025). Insecticidal Evaluation and Structure-Activity Relationship Study of Some Synthesized Urea and Thiourea Derivatives Against Spodoptera Littoralis (Boisd.). EKB Journal Management System, 10(4), 513-517. doi: 10.21608/sjsci.2025.359928.1257
Nabila Ali Ahmed Abdal majeed Ali Ahmed Abdal majeed; Ahmed Mohamed Mohamed El saghier; Mohamed A. Gad; Safwat A. Aref; Antar A. Abdlhamid. "Insecticidal Evaluation and Structure-Activity Relationship Study of Some Synthesized Urea and Thiourea Derivatives Against Spodoptera Littoralis (Boisd.)". EKB Journal Management System, 10, 4, 2025, 513-517. doi: 10.21608/sjsci.2025.359928.1257
Abdal majeed, N., El saghier, A., Gad, M., Aref, S., Abdlhamid, A. (2025). 'Insecticidal Evaluation and Structure-Activity Relationship Study of Some Synthesized Urea and Thiourea Derivatives Against Spodoptera Littoralis (Boisd.)', EKB Journal Management System, 10(4), pp. 513-517. doi: 10.21608/sjsci.2025.359928.1257
Abdal majeed, N., El saghier, A., Gad, M., Aref, S., Abdlhamid, A. Insecticidal Evaluation and Structure-Activity Relationship Study of Some Synthesized Urea and Thiourea Derivatives Against Spodoptera Littoralis (Boisd.). EKB Journal Management System, 2025; 10(4): 513-517. doi: 10.21608/sjsci.2025.359928.1257

Insecticidal Evaluation and Structure-Activity Relationship Study of Some Synthesized Urea and Thiourea Derivatives Against Spodoptera Littoralis (Boisd.)

Sohag Journal of Sciences
Volume 10, Issue 4 - Serial Number 3, December 2025, Pages 513-517    PDF (436.16 K)
Document Type: Regular Articles
DOI: 10.21608/sjsci.2025.359928.1257
Authors
Nabila Ali Ahmed Abdal majeed Ali Ahmed Abdal majeed* 1; Ahmed Mohamed Mohamed El saghier2; Mohamed A. Gad3; Safwat A. Aref4; Antar A. Abdlhamid5
1Plant Protection Research Institute, Agriculture Research Centre, Dokki, Cairo
2chemistry department, Faculty of Science, Sohag University, Sohag, Egypt
3Research Institute of Plant Protection, Agricultural Research Center, 12619 Giza, Egypt.
4Plant Protection Research Institute, Agriculture Research Centre, Dokki,Cairo
5Chemistry Dept., Faculty of Science Sohag University
Abstract
Because utilizing insecticides can cause some serious issues, finding safe options to these chemicals has become decisive. So, in order to create novel Hexaflumuron analogues as insect growth regulators that could be screened & tested against Spodoptera littoralis (Boisd), urea and thiourea derivatives that were projected to be toxicologically active were synthesized in pure form. An equimolecular amount of 4-nitroanaline was added with stirring to phenyl isocyanate and phenyl isothiocyanate in dry 1,4-dioxane. By using spectroscopic and elemental investigations, the structure of synthesized substances was determined. Target compounds 3a and 3b had moderate insecticidal toxicity; their LC50 values for the second larval instar were determined to be 147.26 and 316.01 mg/L, respectively, whereas the LC50 value for the reference insecticide, hexaflumuron, was 17.01 mg/L. Finally, this work further demonstrates the anti-proliferation of S. littoralis and discusses how to discover novel target compounds that may one day be employed as effective insecticidal agents.
Keywords
Urea; Thiourea; Insecticides; Spodoptera littoralis; Hexaflumuron
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