TRIAL FOR DETECTION OF COLICIN-PRODUCING ESCHERICHIA COLI | ||
| Journal of the Egyptian Veterinary Medical Association | ||
| Volume 84, Issue 1, April 2024, Pages 47-55 PDF (537.44 K) | ||
| Document Type: Original Research Articles | ||
| Abstract | ||
| Avian colibacillosis,a critical disease in poultry,is caused byGram-negative Enterobacteriaceae avian pathogenic E. coli APEC. APEC is responsible for many infections, such as septicemia, chronic respiratory disease, swollen-head syndrome, enteritis, cellulitis, salpingitis, omphalitis, synovitis, pericarditis, and peritonitis. Antibiotic-resistant pathogens are an emerging threat, so an alternative to antibiotics is necessary. Colicins are high-molecular-weight proteins of antimicrobial effect that affect phylogenetically relevant bacteria. They do not sacrifice for the microbiota and are not harmful to human cells but only to bacteria carrying the protein receptors BtuB, Cir, FhuA, and OmpF. The study investigates the in vitro inhibitory effect of colicin- producing E. coli from different sources of animals and humans on APEC. They use various mechanisms of action and distinct receptor or translocation systems to avoid mutation and resistance in receptor or translocation systems. Eighteen isolates were detected from 35 chicken organ samples. Four isolates were retrieved from 10 fecal sheep samples. Five isolates were obtained from 10 fecal cat samples. Fifteen isolates were revealed from 18 fecal cow samples. Eleven isolates were from 17 human urine samples. Fifty-three isolates were isolated from 90 samples (58.88%). Non-avian isolates did not have a colicin inhibitory effect on avian pathogenic Escherichia coli APEC. APEC antibiotic resistance for almost all antibiotics is partly responsible for therapeutic failure. Moreover, antibiotic-resistant APEC may possess a zoonotic potential. Consequently, antibiotic alternatives such as colicins may prove useful tools in antibiotics-resistant APEC control without antibiotics drawbacks. | ||
| Keywords | ||
| E. coli; Avian pathogenic E. coli; colibacillosis; poultry; human uropathogenic E. coli; sheep; cow; cat; colicins; Egypt | ||
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