Effect of Intraoperative Glucose Infusion on Blood Glucose Levels in Dogs. | ||
| Journal of Veterinary Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 23 November 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jvmr.2025.427448.1138 | ||
| Authors | ||
| Masao Arisato1; Shozo Okano* 2 | ||
| 1Hyogo Pet Medical Center, 3-1-5 Tachibana-cho, Amagasaki-city, Hyogo, Japan | ||
| 2School of Veterinary Medicine, Kitasato University, Aomori, Japan | ||
| Abstract | ||
| Perioperative glucose management is essential to prevent metabolic complications in surgical patients. Dogs fasted before general anesthesia may develop hypoglycemia, especially if young or malnourished, whereas surgical stress can induce hyperglycemia, increasing postoperative risks. Although optimal infusion rates have been studied in humans, data in dogs are limited. This study evaluated intraoperative glucose infusion rates in canine surgical patients. Fifty-three dogs without endocrine disorders undergoing surgery at Kitasato University Veterinary Teaching Hospital were assigned to four groups: control (no glucose), 0.1 g/kg/hr, 0.2 g/kg/hr, and 0.5 g/kg/hr. Standardized anesthetic protocols were used. Blood glucose was measured preoperatively and upon recovery. In the control group, levels decreased slightly (101.4 ± 14.4 to 98.0 ± 20.1 mg/dl), with some dogs nearing mild hypoglycemia. In the 0.1 g/kg/hr group, glucose rose significantly (92.5 ± 11.8 to 120.6 ± 25.6 mg/dl, P<0.01) but remained within a safe range. In contrast, 0.2 g/kg/hr (98.5 ± 15.8 to 153.5 ± 43.5 mg/dl, P<0.01) and 0.5 g/kg/hr (91.0 ± 7.3 to 183.2 ± 65.7 mg/dl, P<0.05) caused marked increases, with some dogs exceeding 200 mg/dl, indicating hyperglycemia. These results showed that while intraoperative glucose prevents hypoglycemia, excessive infusion predisposes to stress-induced hyperglycemia and related complications. Among the tested rates, 0.1 g/kg/hr maintained stable glycemic control without adverse excursions, supporting its recommendation as the optimal intraoperative glucose infusion rate for routine anesthesia and surgery in dogs. | ||
| Keywords | ||
| Blood Glucose; Dogs; Intraoperative Glucose Infusion; Perioperative Management | ||
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