Pharmacological and biochemical aspects of co-administration of doxycycline and Colistin sulphate against experimentally induced Salmonella typhimurium infection in chicken | ||
| Biological and Biomedical Journal | ||
| Volume 3, Issue 2, July 2025, Pages 276-285 PDF (363.42 K) | ||
| Document Type: Research Articles | ||
| DOI: 10.21608/bbj.2025.418450.1134 | ||
| Authors | ||
| Reham A Mahmoud* 1; Shimaa M Abdelmageed2; Randa M Khallaf3 | ||
| 1Pharmacology and Pyrogen Unit, Department of Biochemistry, Toxicology and Feed Deficiency, Animal Health Research Institute, Agricultural Research Center, Egypt. | ||
| 2Department of Microbiology, Animal Health Research Institute, Agricultural Research Center, Benha, Egypt | ||
| 3Medical Chemistry Unit, Department of Biochemistry, Toxicology and Feed Deficiency, Animal Health Research Institute, Agricultural Research Center, Giza, Egypt. | ||
| Abstract | ||
| Globally, Salmonella is considered one of the most infectious zoonotic pathogens. New approaches to reduce the transmission of Salmonella by food and other routes must be enforced to limit its infectious spread. The current study aimed to assess biochemical and pharmacological effects of administration of either doxycycline, colistin sulphate, or their combination on chicken experimentally infected with Salmonella typhimurium. A total of 25 healthy chickens were divided equally into 5 groups. Group (1) as control. Group (2): Orally infected with S. typhimurium. Group (3): Orally infected with S. typhimurium before being administered doxycycline. Group (4): Orally infected with S. typhimurium before being administered with colistin sulphate. Group (5): Treated with doxycycline and colistin sulphate after S. typhimurium infection. The result illustrated a significant increase in kidney function, as reflected in creatinine, blood urea nitrogen, and liver enzymes, alanine aminotransferase, and aspartate aminotransferase, after S. typhimurium infection. At the same level, the results showed an elevation in interleukin-6 in Group 2 when compared with control; this increase was improved after either doxycycline, colistin sulphate or their combination treatment. In conclusion, this study found that either doxycycline treatment or colistin sulphate and their combination are considered a promising treatment for S. typhimurium infection. | ||
| Keywords | ||
| Antibiotic resistance; Chicken; Doxycycline; Salmonella typhimurium; Colistin sulphate | ||
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