Evaluation of Cognitive Impairment in Multiple Sclerosis
Helal, A., Eissa, A., Zarad, C., Elsherifi, S. (2025). Evaluation of Cognitive Impairment in Multiple Sclerosis. EKB Journal Management System, (), -. doi: 10.21608/muj.2025.433631.1272
Ahmed Rezk Helal; Ahmed Hamed Eissa; Carmen Ali Zarad; Saad Shawki Elsherifi. "Evaluation of Cognitive Impairment in Multiple Sclerosis". EKB Journal Management System, , , 2025, -. doi: 10.21608/muj.2025.433631.1272
Helal, A., Eissa, A., Zarad, C., Elsherifi, S. (2025). 'Evaluation of Cognitive Impairment in Multiple Sclerosis', EKB Journal Management System, (), pp. -. doi: 10.21608/muj.2025.433631.1272
Helal, A., Eissa, A., Zarad, C., Elsherifi, S. Evaluation of Cognitive Impairment in Multiple Sclerosis. EKB Journal Management System, 2025; (): -. doi: 10.21608/muj.2025.433631.1272

Evaluation of Cognitive Impairment in Multiple Sclerosis

Medicine Updates
Articles in Press, Accepted Manuscript, Available Online from 25 November 2025
Document Type: Review Article
DOI: 10.21608/muj.2025.433631.1272
Authors
Ahmed Rezk Helal* 1; Ahmed Hamed Eissa2; Carmen Ali Zarad3; Saad Shawki Elsherifi4
1Port said university hospital , neuropsychiatry department
2Professor and Chairman of Neuropsychiatry - Faculty of Medicine Port-said University
3Assistant Professor in Diagnostic Radiology - Faculty of Medicine Port-said University
4Assistant professor of Neurology - Faculty of Medicine Port-said University
Abstract
Multiple Sclerosis (MS) is a chronic, neurodegenerative disorder of the CNS affecting over 2.8 million people globally. Cognitive impairment (CI) is a highly prevalent manifestation, affecting 34% to 65% of patients across all stages. CI is a significant prognostic factor, accelerating disability progression and increasing mortality risk. A dominant feature is a slowdown in information processing speed (IPS).
CI pathogenesis involves widespread white and grey matter damage leading to a functional "network collapse". Advanced MRI techniques, revealing cortical lesions and grey matter atrophy, strongly correlate with cognitive decline. Routine screening utilizes the Symbol Digit Modalities Test (SDMT).
Crucially, no medications are currently approved specifically for MS-related CI. The most robust evidence supports non-pharmacological interventions, prioritizing cognitive training and rehabilitation, including the modified Story Memory Technique. Comprehensive management must also address concomitant factors like depression, fatigue, and sleep disorders. as these are significant contributors to CI. Routine monitoring and screening for these "hidden symptoms" are essential for a complete assessment and effective intervention.
Keywords
Multiple sclerosis; Cognitive impairment; MRI
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