Association between Ca+2 / Mg+2ATPase activity and Type 2 diabetic patients with nephropathy | ||
| Biochemistry Letters | ||
| Article 6, Volume 14, Issue 1, 2018, Pages 79-84 PDF (713.95 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/blj.2018.47585 | ||
| Authors | ||
| Mohamed A. Abosheasha1; Faten Zahran1; Sahar S. Bessa2; Tarek M. Mohamed3 | ||
| 1Biochemistry Department, Faculty of science, Zagazig university, Zagazig, Egypt | ||
| 2Internal medicine Department, Faculty of medicine, Tanta University, Tanta, Egypt. | ||
| 3Biochemistry Section, Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt. | ||
| Abstract | ||
| Diabetic nephropathy (DN) is a major cause of sickness and death in people with diabetes. It can lead to the need for dialysis or a kidney transplant. Ca+2 / Mg+2ATPase is an important regulator of intracellular calcium concentration and therefore, of erythrocyte deformability. So the present study was aimed to evaluate the erythrocyte Ca+2 / Mg+2ATPase activity in type 2 diabetes patients and reveal any associations between enzyme activity and diabetic nephropathy. The study included sixty patients with type 2 diabetes who were subdivided into thirty with nephropathy (microalbuminuria and macroalbuminuria) and thirty without complications. Twenty healthy subjects, age- and sex- matched were included as control group. Patients and controls were assessed for FBG, PBG, glycosylated hemoglobin (HbA1c), serum creatinine and urea levels, lipid profile and fasting C-peptide level, microalbuminuria and Ca+2 / Mg+2ATPase activity. The results showed that a significant decrease in Fasting C-Peptide of patients with diabetic nephropathy group as either compared with diabetic without complication or control group. Moreover there was a significant decrease in Ca+2/Mg+2 ATPase activity among patients with type 2 diabetes and with or without nephropathy as compared with control group. Also enzyme activity did not differ among the degrees of nephropathy. Thus, alteration of Ca+2/Mg+2 ATPase activity and Fasting C-Peptide may be recognized features of Type 2 diabetes mellitus. | ||
| Keywords | ||
| Diabetes mellitus; Ca+2/Mg+2 ATPase; C-peptide; diabetic nephropathy | ||
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