Properties of Crocus sativus Saffron on DEN-induced Hepatocellular Carcinoma in Rats | ||
| Biochemistry Letters | ||
| Article 14, Volume 14, Issue 1, 2018, Pages 171-179 PDF (516.84 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/blj.2018.47618 | ||
| Authors | ||
| Reda Fikry; Nabila Zein; Asmaa Faozan | ||
| Chemistry Department-Faculty of Science, Zagazig university, Egypt | ||
| Abstract | ||
| The purpose of this study was to investigate the possible mechanisms of Crocus sativus saffron against diethylnitrosamine (DEN)-induced liver cancer in rats. Administration of Crocus sativus saffron at a dose of 300 mg/kg/day was started 2 weeks prior to the DEN and CCL4 injection and was continued for 42 days. Crocus sativus saffron significantly reduced the DEN-induced increase in the number and the incidence of hepatic dyschromatic nodules, saffron restored the superoxide dismutase, catalase and malondialdehyde levels and increased the expression of active caspase 3 and inhibited the formation of MMP9 | ||
| Keywords | ||
| Saffron; DEN; CCl4; HCC; caspase and MMP | ||
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