Pyrrolopyrimidine: A Versatile Scaffold for Construction of Targeted Anti-cancer Agents | ||
| Journal of Advanced Pharmacy Research | ||
| Article 1, Volume 2, Issue 1, January 2018, Pages 1-19 PDF (507.11 K) | ||
| Document Type: Review Article | ||
| DOI: 10.21608/aprh.2017.4832 | ||
| Authors | ||
| Mai Adel* ; Rabah A. T. Serya; Deena S. Lasheen; Khaled A A. M. Abouzid | ||
| Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt | ||
| Abstract | ||
| Pyrrolopyrimidine derivatives comprise a class of biologically active heterocyclic compounds that are well known to play a critical role in pharmaceutical drug design and health care. The pyrrolopyrimidines serve as promising scaffolds that were found in a number of biologically active compounds including antibiotics, anti-inflammatory, anti-viral and anticancer. Researchers were inspired to develop novel pyrrolopyrimidine derivatives for the treatment of Cancer. Currently several pyrrolopyrimidines are available commercially as anticancer drugs. The present review article offers a detailed account on the development of pyrrolopyrimidine derivatives with anticancer potential with emphasis on their activity as targeted kinase inhibitors. | ||
| Keywords | ||
| Anti-cancer; Protein kinases; Pyrrolopyrimidine | ||
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