Human Brucellosis: Methods of Diagnosis and Risk Factors among Egyptian Patients admitted at Assiut Fever Hospital .
El-Moselhy, E., Soliman, T., Abd El-Rahman, A., El-Tiby, D., Amin, H., Badr, B. (2020). Human Brucellosis: Methods of Diagnosis and Risk Factors among Egyptian Patients admitted at Assiut Fever Hospital .. EKB Journal Management System, 1(1), 1-13. doi: 10.21608/jram.2019.13953.1013
Essam A. El-Moselhy; Tahseen S. Soliman; Ayman A. Abd El-Rahman; Diaa M. El-Tiby; Hesham H. Amin; Bahaa M. Badr. "Human Brucellosis: Methods of Diagnosis and Risk Factors among Egyptian Patients admitted at Assiut Fever Hospital .". EKB Journal Management System, 1, 1, 2020, 1-13. doi: 10.21608/jram.2019.13953.1013
El-Moselhy, E., Soliman, T., Abd El-Rahman, A., El-Tiby, D., Amin, H., Badr, B. (2020). 'Human Brucellosis: Methods of Diagnosis and Risk Factors among Egyptian Patients admitted at Assiut Fever Hospital .', EKB Journal Management System, 1(1), pp. 1-13. doi: 10.21608/jram.2019.13953.1013
El-Moselhy, E., Soliman, T., Abd El-Rahman, A., El-Tiby, D., Amin, H., Badr, B. Human Brucellosis: Methods of Diagnosis and Risk Factors among Egyptian Patients admitted at Assiut Fever Hospital .. EKB Journal Management System, 2020; 1(1): 1-13. doi: 10.21608/jram.2019.13953.1013

Human Brucellosis: Methods of Diagnosis and Risk Factors among Egyptian Patients admitted at Assiut Fever Hospital .

Journal of Recent Advances in Medicine
Article 1, Volume 1, Issue 1, March 2020, Pages 1-13    PDF (473.76 K)
Document Type: Original Article
DOI: 10.21608/jram.2019.13953.1013
Authors
Essam A. El-Moselhy1; Tahseen S. Soliman2; Ayman A. Abd El-Rahman3; Diaa M. El-Tiby4; Hesham H. Amin5; Bahaa M. Badr6
1Community Medicine Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
2Community Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
3Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
4Tropical Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
5Clinical Pathology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
6Medical Microbiology and Immunology Department, Faculty of Medicine, Al-Azhar University, Assiut, Egypt.
Abstract
Background: Human brucellosis, a common zoonotic disease, is major public health problem in many countries worldwide including Egypt. Objectives: To define brucellosis patients’ risk-factors and to assess diagnostic lab methods of brucellosis at Assiut Fever Hospital. Patients and Methods: The study recruited 98 patients with brucellosis and an equal number of controls. All participants were subjected to interview, clinical examination, and lab investigations. Results: Older age, males, rural residence, low socioeconomic status were significant risk-factors (OR=3.76, 2.04, 2.86, 2.72; respectively). Occupations had animals’ contact were significant risk-factor (OR=4.7); the most risky were butchers/slaughter workers (OR=8.0) and farmers/dairy workers (OR=3.59). Longer occupational exposure was risk-factor (OR=15.57). The main significant presenting symptoms were fever and muscloskeletal affections. The main significant signs were high temperature and hepato- and spleno-megaly. Standard agglutination test (SAT) titer 1/320 was the cut-off point for diagnosis and significantly lies in area under the ROC curve, sensitivity=96.4% and specificity=100.0%. Blood culture was positive in 58.2% of cases with no significant differences between SAT titer and blood culture positivity. ELISA IgM and IgG results were positive in 69.4% and 65.3% of the cases with no significant differences between SAT titer and IgM and IgG results. Conclusions: Human brucellosis has many preventable risk-factors; its diagnosis depends mainly on presence of risk-factors, clinically suspected, and SAT titer ≥1/320.
Keywords
Keywords: Brucellosis; Clinical; Diagnosis; Risk-Factors; Sociodemographic
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