Effects of chronic hepatitis B infection and viremia on the reproductive potential of Egyptian males | ||
| Human Andrology | ||
| Article 2, Volume 8, Issue 4, December 2018, Pages 106-109 PDF (364.03 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ha.2019.4844.1033 | ||
| Authors | ||
| Kamal Abd El-Hafez1; Ehab Fawzy2; Emad Kamal3; Sahar Hassan4; Mohammed Zakaraia5; Rofaida R. Shehata6 | ||
| 1Departments of Dermatology and Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||
| 2Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt | ||
| 3Departments of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||
| 4Gastroenterology and Tropical Medicine Faculty of Medicine, Assiut University, Assiut, Egypt | ||
| 5Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||
| 6Department of Dermatology and Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut Egypt | ||
| Abstract | ||
| Purpose: To evaluate the effect of chronic hepatitis B infection on semen parameters and reproductive hormones in Egyptians. Patients and methods: In this study, 104 males were included. They were classified into two groups: 73 patients with chronic hepatitis B without liver cirrhosis (group 1) and 31 healthy volunteers (group 2). Semen samples were analyzed using a computer-aided semen analyzer. Serum levels of follicle-stimulating hormone, luteinizing hormone, total testosterone, free testosterone, estradiol, prolactin, and sex hormone-binding globulin were measured by enzyme-linked immunosorbent assay. PCR was also evaluated. Liver condition was evaluated by liver function tests and abdominal sonography. Results: Semen parameters were affected in patients. There was a significant negative correlation between semen parameters (sperm count, motility, and morphology) and level of viremia. Moreover, a significant negative correlation was detected between level of viremia and serum levels of free testosterone and follicle-stimulating hormone. However, a positive correlation was noted between level of viremia and serum levels of prolactin and estradiol. Conclusion: Hepatitis B virus may have profound implications on male fertility potential. | ||
| Keywords | ||
| HepatitisB; PCR; Hormones; Semen | ||
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