Effects of chronic hepatitis B infection and viremia on the reproductive potential of Egyptian males
Abd El-Hafez, K., Fawzy, E., Kamal, E., Hassan, S., Zakaraia, M., Shehata, R. (2018). Effects of chronic hepatitis B infection and viremia on the reproductive potential of Egyptian males. EKB Journal Management System, 8(4), 106-109. doi: 10.21608/ha.2019.4844.1033
Kamal Abd El-Hafez; Ehab Fawzy; Emad Kamal; Sahar Hassan; Mohammed Zakaraia; Rofaida R. Shehata. "Effects of chronic hepatitis B infection and viremia on the reproductive potential of Egyptian males". EKB Journal Management System, 8, 4, 2018, 106-109. doi: 10.21608/ha.2019.4844.1033
Abd El-Hafez, K., Fawzy, E., Kamal, E., Hassan, S., Zakaraia, M., Shehata, R. (2018). 'Effects of chronic hepatitis B infection and viremia on the reproductive potential of Egyptian males', EKB Journal Management System, 8(4), pp. 106-109. doi: 10.21608/ha.2019.4844.1033
Abd El-Hafez, K., Fawzy, E., Kamal, E., Hassan, S., Zakaraia, M., Shehata, R. Effects of chronic hepatitis B infection and viremia on the reproductive potential of Egyptian males. EKB Journal Management System, 2018; 8(4): 106-109. doi: 10.21608/ha.2019.4844.1033

Effects of chronic hepatitis B infection and viremia on the reproductive potential of Egyptian males

Human Andrology
Article 2, Volume 8, Issue 4, December 2018, Pages 106-109    PDF (364.03 K)
Document Type: Original Article
DOI: 10.21608/ha.2019.4844.1033
Authors
Kamal Abd El-Hafez1; Ehab Fawzy2; Emad Kamal3; Sahar Hassan4; Mohammed Zakaraia5; Rofaida R. Shehata6
1Departments of Dermatology and Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt
2Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt
3Departments of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt
4Gastroenterology and Tropical Medicine Faculty of Medicine, Assiut University, Assiut, Egypt
5Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
6Department of Dermatology and Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut Egypt
Abstract
Purpose: To evaluate the effect of chronic hepatitis B infection on semen parameters and reproductive hormones in Egyptians.  Patients and methods: In this study, 104 males were included. They were classified into two groups: 73 patients with chronic hepatitis B without liver cirrhosis (group 1) and 31 healthy volunteers (group 2). Semen samples were analyzed using a computer-aided semen analyzer. Serum levels of follicle-stimulating hormone, luteinizing hormone, total testosterone, free testosterone, estradiol, prolactin, and sex hormone-binding globulin were measured by enzyme-linked immunosorbent assay. PCR was also evaluated. Liver condition was evaluated by liver function tests and abdominal sonography.  Results: Semen parameters were affected in patients. There was a significant negative correlation between semen parameters (sperm count, motility, and morphology) and level of viremia. Moreover, a significant negative correlation was detected between level of viremia and serum levels of free testosterone and follicle-stimulating hormone. However, a positive correlation was noted between level of viremia and serum levels of prolactin and estradiol.
Conclusion: Hepatitis B virus may have profound implications on male fertility potential.
Keywords
HepatitisB; PCR; Hormones; Semen
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