Cyanoacetyl urea in heterocyclic synthesis part V: Facile synthesis of poly-functionalized pyrimdines via different behaviors of its free urea amino group | ||
| Egyptian Journal of Chemistry | ||
| Article 19, Volume 61, Issue 1, January and February 2018, Pages 207-212 PDF (462.66 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2018.2297.1190 | ||
| Authors | ||
| Hoda Sabry Othman1; Maher Al-Hashash2; Galal Abd El-Moein Nawwar* 3 | ||
| 1Green Chemistry department, National research centre | ||
| 2Chemistry Department, Faculty of Science, Ain-shams University | ||
| 3Green chemistry department, National Research Centre | ||
| Abstract | ||
| The poly-functional precursor, cyano-acetyl urea, could be utilized in the synthesis of various pyrimidens utilizing its benzothiazole derivative 1. The free amino group in 1 undergoes different chemical behavior according to the reaction conditions to afford pyrimidines 3,4,5,6,7a,b and 9a,b, respectively. | ||
| Keywords | ||
| 1; 3-Benzothiazole; Pyrimidine; Cyanoacetyl urea; small molecules | ||
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