Time and dose-dependent adverse effects of four medicinal plants on male reproductive system | ||
| Human Andrology | ||
| Article 4, Volume 7, Issue 4, December 2017, Pages 136-142 PDF (403.67 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ha.2017.1189.1006 | ||
| Authors | ||
| Ehsanollah Sakhaee* 1; Ladan Emadi2; Heydar Khalili Bagaloy1; Najma Abbasi3 | ||
| 1Department of Clinical Sciences, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran | ||
| 2Department of Basic Sciences, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran | ||
| 3Veterinary Organization of Kerman province, Kerman, Iran. | ||
| Abstract | ||
| Introduction: the point of the present survey was to evaluate time and dose-dependent adverse effects of four restorative herbs on male reproductive system. Methods: the study involved of seventeen distinctive gatherings of ten mice as takes after: group C1 to C4 (Cuminum cyminum), which received 0.1 ml Cuminum cyminum essential oil at dosage of 0.1, 1, 10 and 100 mg/kg/day, respectively. Group R1 to R4 (Rosa damascene), which received 0.1 ml Rosa damascene essential oil at dosage of 0.1, 1, 10 and 100 mg/kg/day, respectively. Group Z1 to Z4 (Zataria multiflora), which received 0.1 ml Zataria multiflora ethanolic extract at dosage of 100, 200, 400 and 800 mg/kg/day, respectively. Group O1 to O4 (Origanum vulgare), which received 0.1 ml Origanum vulgare ethanolic extract at dose of 100, 200, 400 and 800 mg/kg/day, respectively and finally group Normal which got similar amount of normal saline. Results: the results demonstrated that sperm density, mobility and viability in groups R4, O4, Z2, Z3, Z4, C2, C3 and C4 after 4 weeks were altogether diminished in comparison with normal group. Discussion: according to the results, mentioned medicinal plants should not be used frequently for prolonged duration | ||
| Keywords | ||
| Sperm quality; Medicinal plant; Adverse effects; Mice | ||
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