Effectiveness of 14-days course of clarithromycin-based triple therapy as first line therapy for h.pylori infection in egyptian elderly patients
M, S., M., G., A., D., H, E. (2015). Effectiveness of 14-days course of clarithromycin-based triple therapy as first line therapy for h.pylori infection in egyptian elderly patients. EKB Journal Management System, 2(1), 19-26. doi: 10.21608/ejgg.2015.5342
Salamah M; Gad M.; Deghady A.; Elgayar H. "Effectiveness of 14-days course of clarithromycin-based triple therapy as first line therapy for h.pylori infection in egyptian elderly patients". EKB Journal Management System, 2, 1, 2015, 19-26. doi: 10.21608/ejgg.2015.5342
M, S., M., G., A., D., H, E. (2015). 'Effectiveness of 14-days course of clarithromycin-based triple therapy as first line therapy for h.pylori infection in egyptian elderly patients', EKB Journal Management System, 2(1), pp. 19-26. doi: 10.21608/ejgg.2015.5342
M, S., M., G., A., D., H, E. Effectiveness of 14-days course of clarithromycin-based triple therapy as first line therapy for h.pylori infection in egyptian elderly patients. EKB Journal Management System, 2015; 2(1): 19-26. doi: 10.21608/ejgg.2015.5342

Effectiveness of 14-days course of clarithromycin-based triple therapy as first line therapy for h.pylori infection in egyptian elderly patients

The Egyptian Journal of Geriatrics and Gerontology
Article 4, Volume 2, Issue 1, March 2015, Pages 19-26    PDF (328.51 K)
Document Type: Original Article
DOI: 10.21608/ejgg.2015.5342
Authors
Salamah M1; Gad M.1; Deghady A.2; Elgayar H1
1Geriatric Unit, Internal Medicine Department, Faculty of Medicine, Alexandria University
2Clinical Pathology Department, Faculty of Medicine, Alexandria University
Abstract
The aim of the study is to assess the effectiveness of 14-days course of Clarithromycin-based triple therapy as first line therapy for H. pylori infection in Egyptian elderly patients with normal liver and kidney functions. Methods: The study was
experimental study carried out on 34 elderly patients having H. pylori gastritis with normal liver and kidney functions. We tested for H. pylori stool antigen using a quantitative monoclonal enzyme-linked immunosorbent assay (ELISA) assay before and 4 weeks after the treatment to confirm eradication. Patients received Clarithromycin-based triple therapy
(Clarithromycin 500mg twice daily, Amoxicillin 1000mg twice daily, and Omeprazole 40mg twice daily) for H. pylori eradication for 14 days. Results: The cure rate of Clarithromycinbased triple therapy was 88.2% (30/34) and only 11.8% (4/34) was having persistent infection. None of the patients discontinued the drugs indicating good tolerability
.Conclusion: The use of 14-days course of Clarithromycin-based triple therapy as first line therapy for H. pylori infection is highly effective and tolerable in Egyptian elderly patients with normal liver and kidney functions.
Keywords
Helicobacter pylori; Elderly; clarithromycin
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