Volumetric Brain MRI Changes in Schizophrenic Patients | ||||
| The Medical Journal of Cairo University | ||||
| Article 25, Volume 87, June, June 2019, Page 1539-1545 PDF (497.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2019.53573 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| RASHA EL-SHAFEY, M.D.; AHMED MUBARAK, M.D.; ADEL BADAWY, M.D.; RANIA MESHREF, M.Sc. | ||||
| The Departments of Radiodiagnosis* and Neuropsychiatry**, Tanta University Hospital, Tanta, Egypt | ||||
| Abstract | ||||
| Abstract Background: The core symptoms of schizophrenia is associated with changes in volumes of specific regions of the brain. Aim of Study: Is to correlate between Prefrontal Cortex (PFC), Hippocampus, (HC) and Cerebellum (CRM) volumes and schizophrenic core symptoms (cognitive, negative and positive). Methods: The study included twenty schizophrenic patients and 20 matched healthy individuals as control group. DSM-IV-TR was used for diagnosis of Schizophrenia while Positive and Negative Syndrome Scale (PANSS) for symptoms assess-ment. 3D Slicer version 4.2.2 software was used for regional volumetric measurements. Both patients and control were assessed by [Wechsler Memory Scale (WMS), Trail Making test (TM) and Folstein Mini Mental State Examination (MMSE] cognitive tests. Results: Significant decrease of volumes of HC [right, p=0.042,], vermis [p=0.02], right, p=0.25], PFC [left p=0.009, right p=0.006], and CRM [left p=0.041. The scores of WMS sub tests (p<0.005), MMSE (p=0.001) and two stages TM delay time (p<0.01) revealed significant reduction in patients than control. PANSS negative symptoms score revealed negative correlation with vermis (p<0.001) and right CRM lobe volume (p<0.001), while positive correlation between PANSS positive symptoms score and cerebellar vermis (p=0.007) and negative with both HC volumes (p=0.01). Conclusion: Hippocampus, prefrontal cortex, and cere-bellum volumes reduction and correlation with core symptoms help in assessment of the pathophysiology of schizophrenia. | ||||
| Keywords | ||||
| Volumetric; MRI; Schizophrenia | ||||
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