The Effect of Anti Thyroid Medications on the Therapeutic outcome of I-131 in Hyperthyroid Patients with Graves ' disease
younis, J. (2017). The Effect of Anti Thyroid Medications on the Therapeutic outcome of I-131 in Hyperthyroid Patients with Graves ' disease. EKB Journal Management System, 14(14), 28-39. doi: 10.21608/egyjnm.2017.5436
jehan ahmed younis. "The Effect of Anti Thyroid Medications on the Therapeutic outcome of I-131 in Hyperthyroid Patients with Graves ' disease". EKB Journal Management System, 14, 14, 2017, 28-39. doi: 10.21608/egyjnm.2017.5436
younis, J. (2017). 'The Effect of Anti Thyroid Medications on the Therapeutic outcome of I-131 in Hyperthyroid Patients with Graves ' disease', EKB Journal Management System, 14(14), pp. 28-39. doi: 10.21608/egyjnm.2017.5436
younis, J. The Effect of Anti Thyroid Medications on the Therapeutic outcome of I-131 in Hyperthyroid Patients with Graves ' disease. EKB Journal Management System, 2017; 14(14): 28-39. doi: 10.21608/egyjnm.2017.5436

The Effect of Anti Thyroid Medications on the Therapeutic outcome of I-131 in Hyperthyroid Patients with Graves ' disease

Egyptian Journal Nuclear Medicine
Article 3, Volume 14, Issue 14, July 2017, Pages 28-39    PDF (632.19 K)
Document Type: Original Paper, Endocrine
DOI: 10.21608/egyjnm.2017.5436
Author
jehan ahmed younis*
department of Oncology and Nuclear medicine, faculty of medicine, Cairo university, Cairo, Egypt
Abstract
Objective: to detect the effect of antithyroid drugs (ATD) on the therapeutic outcome of I-131 in hyperthyroid Graves' patients. Methods: Retrospective study was done on 200 patients with Graves' disease treated with fixed dose of radioactive iodine (RAI) (12mCi). The patients were classified into three groups: Group I (n = 70) were treated by ATDs for more than 6 months and stopped it 5 days; group II (n = 70) were treated by ATDs for more than 6 months but stopped it only for two days or less, and group III (n = 60) had never been treated with ATD before RAI treatment (control group). Results: There was a statistical significant difference in the cure rate between group I and group II (P < 0.001), group II and group III (P < 0.001), but no significant difference between group I and group III (P = 0.453) three months after RAI therapy. There was a statistical significant difference in the cure rate observed between group I and the group II (P =0.002), group II and group III (P < 0.001), but no significant difference between group I and group III (P =0.060) 6 months after RAI therapy. There was a statistical significant difference between the three groups 3 (P < 0.001), and 6 months (P < 0.001), after RAI therapy.
Conclusion: Administration of ATDs more than 6 month without discontinuation decreased response of RAI treatment in 3 and 6 months' follow-up. Discontinuation of ATDs for 5 days before RAI treatment is recommended.

Keywords
Graves' disease; Ant thyroid drug; radioactive iodine
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