Protective activities of Nigella sativa and its active gradient thymoquinone on the carcinogenic effects of N-butyl-N-(4-hydroxybutyl)nitrosamine on Wistar rats | ||
| Egyptian Journal of Cancer and Biomedical Research | ||
| Article 4, Volume 2, Issue 2 - Serial Number 3, August 2018, Pages 19-23 PDF (1.7 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcbr.2018.37788 | ||
| Authors | ||
| Elsayed I. Salim* 1; Areeg Khalifa2 | ||
| 1Zoology Department, Faculty of Science, Tanta University, Egypt | ||
| 2Tanta University, Faculty of Science, Department of Zoology | ||
| Abstract | ||
| Background: Carcinogens become a serious environmental challenge. Aim: The main aim of this study was to assess the alterations in some biochemical parameters in male Wistar rats after. Materials and Methods: Experimental groups were administered with 0.05% N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) followed by 5% Sodium ascorbate (Na-As), then they were post-treated with Nigella sativa (N. sativa) by an inter-gastric luminal gavage or with thymoquinone (TQ) by inter-peritoneal injections. Blood samples were collected after a 32 weeks’ experiment. Results: TQ seemed to have a powerful inhibitory effect on total cholesterol and triacylglycerol levels. While levels of A/G ratio, ALT and AST were highly decreased by both of N. sativa and TQ. Conclusion: These findings may rely on the lipid-modifying and hepatoprotective effects of N. sativa crude oil and its main constituent TQ on mammals. Thus, further investigations are required. | ||
| Keywords | ||
| Keywords: N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN); Sodium ascorbate (Na-As); Nigella sativa (N. sativa); Thymoquinone (TQ) | ||
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