Evaluation of Serum Interleukin-6 Level in Vitiligo Patients before and after Phototherapy | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 28, Volume 77, Issue 3, October 2019, Pages 5276-5278 PDF (330.93 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2019.55489 | ||
| Authors | ||
| Amr Mohamed Zaki1; Hassan Mamdouh Abd El Aziz1; Mamdouh Atiah Mohamed2; Ahmed Ayman Mohamed Abd El Hamed* 1 | ||
| 1Department of Dermatology and Venereology, Faculty of Medicine - Al Azhar University | ||
| 2Department of Clinical Pathology, Faculty of Medicine - Al Azhar University | ||
| Abstract | ||
| Background: Vitiligo is an acquired pigmentary disorder of the skin, resulting from a loss of functioning epidermal melanocytes. Multiple pathogenetic factors have been proposed, including the neural theory, genetic predisposition and impaired anti-oxidative defense. Objective: To evaluate the role of interleukin-6 in pathogenesis of vitiligo and the effect Narrow band-UVB on IL-6 serum levels. Patients and Methods: The study included 30 patients with vitiligo and 30 healthy controls. Each was submitted to thorough history taking, complete general, dermatological examinations including VASI score, and assessment of serum interleukin-6 before and after 16 sessions of NB-UVB. Results: Results of this study showed no statistical significant difference between patients and control as regard age and gender. Our study revealed a statistically significant difference between levels of IL-6 in patients group before and after therapy. Conclusion: Knowing exactly the role of IL-6 is important not only to clarify the pathogenesis of this disease, but also to improve the clinical course of vitiligo (i.e., disease stabilization and/or repigmentation) and the quality-of-life of patients. | ||
| Keywords | ||
| Broadband (narowband)UVB; systemic corticosteroids; erythrocyte sedimentation rate | ||
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