BIOMARKERS OF COAGULATION ACTIVATION IN CHILDREN WITH SICKLE CELL DISEASE | ||
| Research Journal of Applied Biotechnology | ||
| Article 13, Volume 3, Issue 1, June 2017, Pages 47-52 PDF (346.78 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/rjab.2017.57644 | ||
| Authors | ||
| Shimaa Dawood* 1; Mohamed A. Soliman2; Mona K. El-Ghamrawy3; Hisham A. Ismail1 | ||
| 1Molecular Diagnostics Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), Sadat City University, Sadat city, Egypt | ||
| 2Clinical Pathology Department, Faculty of Medicine, Menoufiyia University, Menoufiya, Egypt. | ||
| 3Peditric Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt | ||
| Abstract | ||
| Sickle cell disease (SCD) is a multisystem disease, characterized by its multi-phenotypic diversity although being a disease caused by a single nucleotide substitution.In the present study, we measured biomarkers of coagulation activation in children with SCD. The study was performed on 50 Egyptian children with SCD and 41 age- and sex-matched controls. Complete blood picture (CBC), International normalized ratio (INR)and Partial thromboplastin time (PTT) levels were measured. Thrombin-antithrombin (TAT) plasma levels was estimated by enzyme-linked immunosorbent assay (ELISA). A statically significant increase in all of INR, PTT and TAT plasma levels were detected. We agree with the previous studies that children with SCD exhibit a hypercoagulable state. | ||
| Keywords | ||
| Sickle cell disease – Hypercoagulability– Thrombin-Antithrombin | ||
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