Estrogen receptor alpha XbaI polymorphism is associated with higher relaxin-3 levels in women with metabolic syndrome | ||
| Records of Pharmaceutical and Biomedical Sciences | ||
| Article 3, Volume 1, Issue 1, March 2017, Pages 17-21 PDF (643.62 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/rpbs.2018.5916 | ||
| Authors | ||
| Eman T. Mehanna* 1; Noha M. Mesbah1; Maivel H. Ghattas2; Dina M. Abo-Elmatty1 | ||
| 1Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt | ||
| 2Department of Medical Biochemistry, Faculty of Medicine, Port Said University, Port Said, 42526, Egypt | ||
| Abstract | ||
| Relaxin-3 is known to play a role in appetite regulation, increasing food intake and body weight. This study aimed to assess the relation of relaxin-3 with ERS1 XbaI and PvuII polymorphisms. One hundred female patients with metabolic syndrome were investigated. The genotypes of ESR1 XbaI and PvuII polymorphisms were assessed with PCR-RFLP. Serum relaxin-3 level was measured for all participants using ELISA. Higher relaxin-3 levels showed association with the minor GG genotype of ESR-1 XbaI polymorphism but not PvuII polymorphism. | ||
| Keywords | ||
| Plicosepalus acacia; Loranthaceae; antimicrobial activity | ||
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