Investigation of In-Vitro Cytotoxic and Potential Anticancer Activities of Flavonoidal Aglycones from Egyptian Propolis
Ibrahim, R., Seif El-Din, A., Abu-Serie, M., Abd El Rahman, N., El-Demellawy, M., Metwally, A. (2017). Investigation of In-Vitro Cytotoxic and Potential Anticancer Activities of Flavonoidal Aglycones from Egyptian Propolis. EKB Journal Management System, 1(2), 13-20. doi: 10.21608/rpbs.2018.5924
Reham Ibrahim; Ahmed Seif El-Din; Marwa Abu-Serie; Nevine Abd El Rahman; Maha El-Demellawy; Aly Metwally. "Investigation of In-Vitro Cytotoxic and Potential Anticancer Activities of Flavonoidal Aglycones from Egyptian Propolis". EKB Journal Management System, 1, 2, 2017, 13-20. doi: 10.21608/rpbs.2018.5924
Ibrahim, R., Seif El-Din, A., Abu-Serie, M., Abd El Rahman, N., El-Demellawy, M., Metwally, A. (2017). 'Investigation of In-Vitro Cytotoxic and Potential Anticancer Activities of Flavonoidal Aglycones from Egyptian Propolis', EKB Journal Management System, 1(2), pp. 13-20. doi: 10.21608/rpbs.2018.5924
Ibrahim, R., Seif El-Din, A., Abu-Serie, M., Abd El Rahman, N., El-Demellawy, M., Metwally, A. Investigation of In-Vitro Cytotoxic and Potential Anticancer Activities of Flavonoidal Aglycones from Egyptian Propolis. EKB Journal Management System, 2017; 1(2): 13-20. doi: 10.21608/rpbs.2018.5924

Investigation of In-Vitro Cytotoxic and Potential Anticancer Activities of Flavonoidal Aglycones from Egyptian Propolis

Records of Pharmaceutical and Biomedical Sciences
Article 3, Volume 1, Issue 2, September 2017, Pages 13-20    PDF (860.7 K)
Document Type: Original Article
DOI: 10.21608/rpbs.2018.5924
Authors
Reham Ibrahim* 1; Ahmed Seif El-Din2; Marwa Abu-Serie3; Nevine Abd El Rahman4; Maha El-Demellawy3, 5; Aly Metwally2
1Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt
2Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt
3Medical Biotechnolog Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, Egypt
4Pharmaceutical & Fermentation Industries Development Center, City of Scientifc Research and Technological Applications, Alexandria, Egypt
5Pharmaceutical & Fermentation Industries Development Center, City of Scientific Research and Technological Applications, Alexandria, Egypt
Abstract
The in-vitro anticancer activity of Egyptian propolis ethanol extract as well as two isolated flavonoidal aglycones, tectochrysin and quercetin-3,3’-di-O-methylether,was assayed using neutral red uptake method on human breast cancer (MCF-7) and colorectal adenocarcinoma (Caco-2) cell lines, in addition to their in-vitro cytotoxic effect to normal human peripheral blood mononuclear cells (PBMCs). Egyptian propolis ethanol extract and quercetin-3,3’-di-O-methylether showed both high activity and selectivity towards the two tested cell lines suggesting them as effective, safe and selective anticancer candidates against both breast and colorectal cancer.
Keywords
Propolis; Flavonoidal aglycones; In-vitro anticancer activity
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