Does Podocyte-Associated Protein Has A Role in Early Detection of Diabetic Nephropathy in Type 2 Diabetes Mellitus? | ||
| The Medical Journal of Cairo University | ||
| Article 15, Volume 87, September, September 2019, Pages 2817-2825 PDF (1.06 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcu.2019.59311 | ||
| Authors | ||
| MOHAMED A.R. EL-ZAMAR, M.Sc.; OLA A.F. EL-SHORA, M.D.; GHADA M. AL-GHAZALY, M.D.; MOHAMED H. ABO FREIKHA, M.D. | ||
| The Department of Internal Medicine, Faculty of Medicine, Tanta University, Egypt | ||
| Abstract | ||
| Abstract Background: Diabetic nephropathy or Diabetic Kidney Disease (DKD) became a major public health concern world-wide because it is a major cause of end stage renal disease. Early intervention can significantly improve the prognosis. Urinary podocyte-associated protein is elevated in patients with DKD, so it is a promising way in early detection of DKD. Aim of Study: To investigate the role of podocyte associated protein in early detection of diabetic nephropathy in patients with type 2 diabetes mellitus. Patients and Methods: A cross sectional study was done on 90 patients divided equally into three groups (normoalbu-miuria, microalbumiuria and macroalbumiuria) plus 10 healthy individuals as controls. Results: All diabetic patients had a higher level of urinary podocyte-associated protein than control group. Also, there was positive correlation between urinary podocyte-associated protein and the degree of albuminuria. So, it was increased with the severity of renal involvement. Conclusion: This study demonstrated that measurement of urinary podocyte-associated protein is a potential biomarker for the early detection of DKD. | ||
| Keywords | ||
| Diabetic kidney disease; Podocyte associated protein; Type 2 diabetes mellitus | ||
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