Urinary Cyclophilin: A New Marker for Diabetic Nephropathy | ||
| The Medical Journal of Cairo University | ||
| Article 134, Volume 86, September, September 2018, Pages 3231-3235 PDF (507.2 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcu.2018.60291 | ||
| Authors | ||
| ENGY A. EBRAHIM, M.D.; ENAAM S. ABD EL-BAR, M.D.; SHEREEN A. ABD EL-SALAM, M.D.; HEND M. EL-ZAREEF, M.Sc. | ||
| The Department of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt | ||
| Abstract | ||
| Abstract Background: Nephropathy is a significant cause of mor-bidity and mortality in patients with Diabetes Mellitus (DM). The condition is characterized by persistent albuminuria and may be decline in the Glomerular Filtration Rate (GFR). Urinary cyclophillin A has been proposed as a simple, accurate and rapid endogenous marker for DN. Aim of Study: To assess the value of urinary cyclophillin A anew marker of diabetic nephropathy. Subjects and Methods: Group I: 60 patients with type 2 diabetes mellitus which will be subdivided into: (A) 30 diabetic patients with diabetic nephropathy. (B) 30 diabetic patients without diabetic nephropathy. Group II: 30 healthy persons as a control group. Results: There was significance association between urinary cyclophillin A and serum creatinine, blood urea, 24 h protein collection and ACR. Urinary cyclophilin A found higher in diabetic nephropathy patients than diabetic patients without nephropathy so it is a new marker for diabetic nephropathy. Conclusion: The results of this study suggest that urinary cyclophillin A new marker for diabetic nephropathy. | ||
| Keywords | ||
| Type 2 diabetes mellitus – Diabetic nephropathy – Urinary cyclophillin A | ||
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