Evaluation of Brain Volume Loss in Different Clinical Types of Multiple Sclerosis Patients | ||||
| The Medical Journal of Cairo University | ||||
| Article 140, Volume 86, September, September 2018, Page 3277-3284 PDF (588.96 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2018.60297 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| MUSTAFA M. HASHEM, M.Sc.; TAREK A. RAGEH, M.D.; AMR F. MOURAD, M.D.; HASSAN M. FARWEEZ, M.D. | ||||
| The Departments of Neurology & Psychiatry* and Radiology**, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Abstract Background: Brain atrophy is an important imaging biomarker in predicting future disability and progression of disease in multiple sclerosis. Aim of Study: We need to evaluate brain volume loss in different clinical types of MS and correlates it with physical disability using NeuroQuaqnt 2.0 automated volumetric meas-urement of brain atrophy in MS. Material and Methods: We conducted the following study on 40 MS patients (4 CIS, 8 PPMS, 22 RRMS and 6 SPMS) for clinical evaluation, assessment their physical disability by (EDSS) and automated volumetric measurement of 3 parameters (whole brain, lateral ventricles and thalami vol-umes) by obtain 3D T1 non contrast, saggital MRI scan by using new software (NeuroQuant®2.0 automated volumetric measurement of brain atrophy) of MS patients. Results: Thalami atrophy was predominant atrophy in 24 patients. Also, it was predominant atrophy in different clinical types (2 CIS, 4 PPMS, 12 RRMS and 6 SPMS) patients. Morphometry results were correlated with physical disability (whole brain volume r=–0.400, p=0.026), (thalami volume r=–0.379, p=0.016), and (lateral ventricles volume r=0.365, p=0.044). MS patients with (disease duration >1 year) had significant lower whole brain volume (p=0.037), lower thalami volume (p=0.019) and higher lateral ventricles volumes (p=0.044). Conclusion: Thalami atrophy is a predominant atrophy in different clinical types of MS patients. Thalami atrophy may be used a sole indices in brain atrophy measuring. Brain atrophy correlates with physical disability and progress with duration of illness. | ||||
| Keywords | ||||
| Multiple sclerosis – Brain atrophy – Volumertic MRI | ||||
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