Recent Advances and Surgical Applications of Monoclonal Antibodies | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 19, Volume 77, Issue 5, October 2019, Pages 5668-5676 PDF (353.07 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2019.62667 | ||
| Authors | ||
| Selim Elnemr; Ahmed Abd El Aal Sultan; Samh Massoud Saad Nassar* | ||
| Department of General Surgery, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| Background: Monoclonal antibodies plays an important role in surgical disease practice specially cancers, Crohn's Disease and ulcerative colitits. Monoclonal antibodies is a type of biological therapy that utilizes a person’s natural immune defense system to fight diseases. Monoclonal antibodies for cancers is essentially the stimulation of immune system via a variety of reagents such as vaccines infusion of T cells or cytokines. These reagents reacted through one of several mechanisms: 1- By stimulating the antitumor response either by increasing the number of effector cells or be production one or more soluble mediators such as lymphokines. 2- By decreasing suppressors mechanisms. 3- By altering tumor cells to increase their immunogenicity and make them more susceptible to immunological defenses. 4- By improving tolerance to cytotoxic drugs or radiotherapy such as stimulating bone marrow function with granulocyte colony stimulating factor (G- CSF). Monoclonal antibodies is a type of immunotherapy but there is another types of immunotherapy such as nonspecific immunotherapies and cancer vaccines mechanism of monoclonal antibodies in surgical disease. Objective: This work was aimed to study the role of monoclonal antibodies in surgical disease as a new tool to surgical armamentarium. Conclusion: It could be concluded from this study that monoclonal antibodies helps the body to fight disease and infection. Monoclonal antibodies are used to treat many types of carcinoma and cancers. | ||
| Keywords | ||
| Surgical Applications; Monoclonal Antibodies | ||
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