CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE ROOTS OF SONCHUS OLERACEUS L. GROWING IN EGYPT | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 9, Volume 32, Issue 1, June 2009, Page 189-197 PDF (205.1 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2009.63356 | ||||
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| Author | ||||
| Ehab Saad Elkhayat | ||||
| Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut 71524, Egypt | ||||
| Abstract | ||||
| Phytochemical study of the roots of Sonchus oleraceus L. (Astraceae) growing in Egypt, afforded loliolide 1 for the first time from the genus Sonchus in addition to 15-O-β-glucopyranosyl- 11β,13-dihydrourospermal A 2, ursolic acid 3, lupeol 4, and β- sitosterol-3-O-β-glucopyranoside 5 for the first time from the species. The biological evaluation of the isolated compounds showed cytotoxic activity of 1 and 2 against L5187Y cell line, while compound 2 showed activity against PC33 cell line. In addition to antibacterial activity of compounds 1 and 2 against S. aureus, B. subtilis, E. Coli, and N. gonorrhoea. The structures of the isolated compounds were elucidated using 1D (1H and 13C), 2D (H-H COSY, HMQC and HMBC) NMR and MS spectroscopic data. | ||||
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