HIGH-FAT DIET-INDUCED OBESITY IS ATTENUATED BY DATE SEED EXTRACT IN RAT MODEL | ||||
| Biochemistry Letters | ||||
| Article 3, Volume 10, Issue 1, 2014, Page 28-42 PDF (1.15 MB) | ||||
| DOI: 10.21608/blj.2014.63849 | ||||
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| Authors | ||||
| Sami A. Abd El Aziz1; Sahar H. Orabi2; Eman H. shatia3 | ||||
| 1Professor, Department of biochemistry and chemistry of nutrition, Faculty of veterinary Medicine, Cairo University, Egypt | ||||
| 2Lecturer, Department of biochemistry and chemistry of nutrition, Faculty of veterinary Medicine, Sadat City University, Egypt | ||||
| 3Department of biochemistry and chemistry of nutrition, Faculty of veterinary Medicine, Sadat City University, Egypt | ||||
| Abstract | ||||
| Background: Obesity has been on the increase and is now an international health problem thus early must be control and prevent childhood obesity. Objective: This work was conducted to investigate the biochemical effect of date seed extract on lipid profile and hepatic antioxidant status in experimentally obese rats. Results: In this study 112 male albino Wister rats were involved and were divided randomly into fourth groups (28 rats in each group) and treated as following for 10 weeks: Group 1 served as control and received basal diet Group –II (Positive control obese group) rats were fed on high fat diet, Group III (date seed extract group): rats were fed on basal diet with administered orally date seed extract daily in a dose of 2 ml / kg b. wt. for 10 weeks Group IV rats were fed on high fat diet for 4 weeks followed by administration of date seed extract orally in a dose of 2 ml / kg b. wt. daily for 6 weeks. beside continuation feeding on HFD. The results showed that the daily oral administration of pits of date palm caused decrease in total cholesterol, LDL-cholesterol, VLDL-cholesterol, triglycerides levels, atherogenic indices, glucose and MDA level while caused an increase in HDL-cholesterol, reduced glutathione and superoxide dismutase activity. Concerning liver histopathology, it was found that oral administration of date seed extract decrease fat droplet gradually and retain liver to normal condition. Conclusion: On conclusion the date seeds have the potential to improve serum biochemical values, antioxidant status and normalized hepatic tissue in obese male rats. | ||||
| Keywords | ||||
| High fat diet; Date seed extract; Lipid profile; antioxidant; liver histopathology | ||||
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