Factor V Leiden, Prothrombin and Methylene-tetrahydrofolate reductase genes mutations are associated with recurrent pregnancy losses in Egyptian women
Ghaleb, K., Abdelazim, A., Ali, H. (2014). Factor V Leiden, Prothrombin and Methylene-tetrahydrofolate reductase genes mutations are associated with recurrent pregnancy losses in Egyptian women. EKB Journal Management System, 10(1), 82-90. doi: 10.21608/blj.2014.63855
Khaled I. Ghaleb; Aaser M. Abdelazim; Haytham A. Ali. "Factor V Leiden, Prothrombin and Methylene-tetrahydrofolate reductase genes mutations are associated with recurrent pregnancy losses in Egyptian women". EKB Journal Management System, 10, 1, 2014, 82-90. doi: 10.21608/blj.2014.63855
Ghaleb, K., Abdelazim, A., Ali, H. (2014). 'Factor V Leiden, Prothrombin and Methylene-tetrahydrofolate reductase genes mutations are associated with recurrent pregnancy losses in Egyptian women', EKB Journal Management System, 10(1), pp. 82-90. doi: 10.21608/blj.2014.63855
Ghaleb, K., Abdelazim, A., Ali, H. Factor V Leiden, Prothrombin and Methylene-tetrahydrofolate reductase genes mutations are associated with recurrent pregnancy losses in Egyptian women. EKB Journal Management System, 2014; 10(1): 82-90. doi: 10.21608/blj.2014.63855

Factor V Leiden, Prothrombin and Methylene-tetrahydrofolate reductase genes mutations are associated with recurrent pregnancy losses in Egyptian women

Biochemistry Letters
Article 7, Volume 10, Issue 1, 2014, Pages 82-90    PDF (642.73 K)
DOI: 10.21608/blj.2014.63855
Authors
Khaled I. Ghaleb1; Aaser M. Abdelazim2; Haytham A. Ali2
1Department of cancer biology, National cancer institute, Cairo University, Cairo, Egypt.
2Department of Biochemistry, Faculty of vet. Medicine, Zagazig University, 44511. Zagazig, Egypt
Abstract
 




 Background: Pregnancies are usually associated with increase tendency to thrombosis; many cases are associated with inherited or acquired risks. 
Objective: The present study tested the mutations in Factor V Leiden (FVL) G1691A, prothrombin (PT) G20210A, methylene-tetrahydrofolate reductase (MTHFR) C677T genes, and their association with recurrent pregnancy losses in Egyptian women. 
Results: The study included 150 subjects of a history of one or more recurrent pregnancy losses matched with 100 normal subjects with a history of normal delivery with no complications. FVL G1691A mutation was detected in (38%) of patients and in (5%) of control. PT G20210A mutation was detected in (6%) of patients with no detection in control. MTHFR C677T mutation was detected in (45.4%) of patients and in (4%) of control. Homozygous with mutant alleles for the three studied mutations were detected only among patients not control group. 
Conclusion: There is a significant association between mutations of FVL, PT and MTHFR and recurrent pregnancy loss in Egyptian women. 
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