COMPARATIVE BIOLOGICAL EVALUATION OF FOUR ENDOPHYTIC FUNGI ISOLATED FROM NIGELLA SATIVA SEEDS | ||
| Al-Azhar Journal of Pharmaceutical Sciences | ||
| Article 8, Volume 59, Issue 1, March and April 2019, Pages 123-136 PDF (806.13 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajps.2019.64111 | ||
| Author | ||
| Ahmed Metwaly* | ||
| Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| In this study, a total of four endophytic fungi have been isolated from Nigella sativa (Ranunculaceae) seeds growing in Egypt. The isolated fungi were identified morphologically and microscopically up to species to be; Alternaria pluriseptata, Aspergillus tubingensis, Aspergillus parasiticus and Eurotium pseudoglaucus. The extracts of the all identified fungi were screened biologically for antileukemic, cytotoxic, antimalarial, antileishmanial, antimicrobial, antioxidant and anti-inflammatory activities as well as for cannabinoid and opioid receptor binding affinities. All the examined fungal extracts showed good antileukemic activities with Ic50 values ranging from 0.025 to 0.8 µg/ml, while two of them showed cytotoxic activities against Pig kidney epithelial (LLC-PK1) cells. Two fungal extracts exhibited antimalarial activities, three showed antioxidant activities and two exhibited anti-inflammatory activities | ||
| Keywords | ||
| Endophytic fungi; antileukemic; cytotoxic; Nigella Sativa | ||
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