EVALUATION OF THE TOXIC EFFECTS OF DIFENOCONAZOLE FUNGICIDE (SCORE) ON MALE ALBINO RATS | ||||
| Al-Azhar Bulletin of Science | ||||
| Article 14, Volume 2013, Issue 12, December 2013, Page 33-48 PDF (351.84 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/absb.2013.6417 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| MOHAMED M. SHAHAT* | ||||
| Department of Zoology, Faculty of Science, AL-Azhar University, Assiut, Egypt | ||||
| Abstract | ||||
| This study was designed to estimate the LD50 of Score (difenoconazole) fungicide and evaluate its toxic effects on body weight, liver weight, some biochemical parameters and hematological profiles of male albino rats after chronic oral daily doses (1/20, 1/10 and 1/5 LD.50) for 8 weeks. Rats were divided into 4 groups, the first group (G1) as control group, the other groups (G2, G3 and G4) treated daily with 20,40 and 80 mg/100 g.b.w. for 1, 4 and 8 weeks respectively The medium lethal dose (LD.50) of Score was 400 mg /100g. body weight of adult male rat. Significant decreases in body weight, serum total protein, albumin, globulin, liver DNA and liver RNA, RBCs count, hemoglobin and blood Platelets count However, significantly increase observed in hepatosomatic index, serum enzymes (ALAT, ASAT, ALP and CK), cholesterol, triglyceride, total lipids, serum creatinine and serum bilirubin and WBC's count | ||||
| Keywords | ||||
| Score; Enzymes; protein; biochemical parameters; liver DNA; liver RNA and blood profile | ||||
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