SYNTHESIS OF SOME NOVEL 1, 3, 5-TRISUBSTITUTED [1,2,4]TRIAZOLE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS
Hayallah, A., Heta, H. (2008). SYNTHESIS OF SOME NOVEL 1, 3, 5-TRISUBSTITUTED [1,2,4]TRIAZOLE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS. EKB Journal Management System, 31(2), 375-390. doi: 10.21608/bfsa.2008.64342
Alaa M. Hayallah; Helal F. Heta. "SYNTHESIS OF SOME NOVEL 1, 3, 5-TRISUBSTITUTED [1,2,4]TRIAZOLE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS". EKB Journal Management System, 31, 2, 2008, 375-390. doi: 10.21608/bfsa.2008.64342
Hayallah, A., Heta, H. (2008). 'SYNTHESIS OF SOME NOVEL 1, 3, 5-TRISUBSTITUTED [1,2,4]TRIAZOLE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS', EKB Journal Management System, 31(2), pp. 375-390. doi: 10.21608/bfsa.2008.64342
Hayallah, A., Heta, H. SYNTHESIS OF SOME NOVEL 1, 3, 5-TRISUBSTITUTED [1,2,4]TRIAZOLE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS. EKB Journal Management System, 2008; 31(2): 375-390. doi: 10.21608/bfsa.2008.64342

SYNTHESIS OF SOME NOVEL 1, 3, 5-TRISUBSTITUTED [1,2,4]TRIAZOLE DERIVATIVES AS POTENTIAL ANTIBACTERIAL AGENTS

Bulletin of Pharmaceutical Sciences Assiut University
Article 15, Volume 31, Issue 2, December 2008, Pages 375-390    PDF (240.51 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2008.64342
Authors
Alaa M. Hayallah* 1; Helal F. Heta2
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
2Department of Microbiology and immunology, Faculty of Medicine, Assiut University, Assiut 71526, Egypt
Abstract
In the present work, some new 1,3,5-trisubstituted[1,2,4]triazole derivatives and their Schiff's bases were synthesized. The chemical structure of the target compounds was confirmed by IR, 1H-NMR, 13C-NMR, FAB-MS, EI-HRMS spectra and elemental analyses. The title compounds were tested for their in vitro antibacterial activity against Gram-positive and Gram-negative ones using ampicillin and nalidixic acid as reference drugs. Some of them showed antibacterial activity more significant than the reference drugs.
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