BUCCOADHESIVE TABLETS FOR DELIVERY OF VERAPAMIL HCl: DESIGN, IN-VITRO ANALYSIS AND IN-VIVO EVALUATION | ||
Bulletin of Pharmaceutical Sciences Assiut University | ||
Article 2, Volume 35, Issue 1, June 2012, Pages 17-25 PDF (728.31 K) | ||
Document Type: Original Article | ||
DOI: 10.21608/bfsa.2012.64591 | ||
Authors | ||
Fakhr El Din S. Ghazy; Hanan M. El-Nahas; Mohamed A. Gad; Noura G. Eissa | ||
Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||
Abstract | ||
Buccoadhesive controlled release verapamil HCl tablets have been prepared using mucoadhesive polymers namely; sodium alginate (Na Alg), xanthan gum (XG) and gum tragacanth (GT) either alone or in combination in different ratios 2:8, 8:2, 4:6 and 6:4. The prepared tablets were evaluated for their weight variation, thickness, hardness, friability and dissolution, content uniformity, swelling index, in-vitro adhesion, in-vitro drug release and invivo hypertension study. Tablets containing XG showed the highest swelling index and bioadhesive force. The maximum cumulative % released (100%) was observed in F7, F10 and F11 due to high percent of Na alg. The kinetics studies show that the release follows zero order kinetics except F1 that it obeyes a diffusion model. The buccoadhesive verapamil HCl tablet had suggested being promising for the transmucosal delivery of verapamil HCl and allowing a controlled drug delivery for 6 hrs. | ||
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