SYNTHESIS OF SOME PYRIMIDINE DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITIES | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 3, Volume 28, Issue 1, June 2005, Page 17-25 PDF (188.55 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.2005.64886 | ||||
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Authors | ||||
Wafaa A. Zaghary1; Aida A. El-Azzouny2; Mohammed A. Motaleb3; Mohammed A. Kedr1 | ||||
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, Egypt | ||||
2Department of Pharmaceutical Sciences, National Research Center, Dokki, Giza | ||||
3Hot Labs. Center, Atomic Energy Authority, Cairo, Egypt | ||||
Abstract | ||||
A series of 4-substituted pyrimidines and fused pyrimidine ring system e.g. pyrido[2,3-d] pyrimidine were synthesized and the antitumor activity have been carried out for 8 compounds. Compound 4a also, which carries the pharmacophoric group IDA was tested for the hepatobilliary imaging effect. | ||||
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