SYNTHESIS OF SOME POTENTIAL ANTIESTROGENIC AGENTS
Safwat, H., Hegazy, G., Hassan, G. (2005). SYNTHESIS OF SOME POTENTIAL ANTIESTROGENIC AGENTS. EKB Journal Management System, 28(1), 27-35. doi: 10.21608/bfsa.2005.65181
Hany M. Safwat; Gehan H. Hegazy; Ghaneya S. Hassan. "SYNTHESIS OF SOME POTENTIAL ANTIESTROGENIC AGENTS". EKB Journal Management System, 28, 1, 2005, 27-35. doi: 10.21608/bfsa.2005.65181
Safwat, H., Hegazy, G., Hassan, G. (2005). 'SYNTHESIS OF SOME POTENTIAL ANTIESTROGENIC AGENTS', EKB Journal Management System, 28(1), pp. 27-35. doi: 10.21608/bfsa.2005.65181
Safwat, H., Hegazy, G., Hassan, G. SYNTHESIS OF SOME POTENTIAL ANTIESTROGENIC AGENTS. EKB Journal Management System, 2005; 28(1): 27-35. doi: 10.21608/bfsa.2005.65181

SYNTHESIS OF SOME POTENTIAL ANTIESTROGENIC AGENTS

Bulletin of Pharmaceutical Sciences Assiut University
Article 6, Volume 28, Issue 1, June 2005, Page 27-35  XML PDF (178.28 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2005.65181
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Authors
Hany M. Safwat; Gehan H. Hegazy; Ghaneya S. Hassan
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Abstract
Some novel steroidal arylidene derivatives were synthesized and representative examples were tested for their antiestrogenic activity. The active compounds were subjected for antitumor activity screening. The compounds tested displayed aromatase inhibitory activity as shown by decrease in estradiol and increase in testosterone levels. Further, some compounds were tested for androgenic/anabolic activity. The steroids used for preparation of these arylidene derivatives are the clinically applied: levo-Norgestrel, Testosterone, Mesterolone and Norethisterone.
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