CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA
Ahmed, S., Mesbah, M., Youssef, D., Khalifa, S. (2006). CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA. EKB Journal Management System, 29(1), 151-165. doi: 10.21608/bfsa.2006.65189
Safwat Ahmed; Mostafa Mesbah; Diaa Youssef; Sherief Khalifa. "CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA". EKB Journal Management System, 29, 1, 2006, 151-165. doi: 10.21608/bfsa.2006.65189
Ahmed, S., Mesbah, M., Youssef, D., Khalifa, S. (2006). 'CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA', EKB Journal Management System, 29(1), pp. 151-165. doi: 10.21608/bfsa.2006.65189
Ahmed, S., Mesbah, M., Youssef, D., Khalifa, S. CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA. EKB Journal Management System, 2006; 29(1): 151-165. doi: 10.21608/bfsa.2006.65189

CHEMICAL AND BIOLOGICAL INVESTIGATIONS OF THE RED SEA SPONGE NEGOMBATA CORTICATA

Bulletin of Pharmaceutical Sciences Assiut University
Article 11, Volume 29, Issue 1, 2006, Pages 151-165    PDF (260.43 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2006.65189
Authors
Safwat Ahmed; Mostafa Mesbah; Diaa Youssef; Sherief Khalifa*
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
Abstract
Two new metabolites, a diglyceride ester, corticaglyceride (1) and a sphingolipid, corticaceramide (5) were isolated and characterized from the Red Sea sponge Negombata corticata (Carter). Other previously reported compounds including nervonic acid (2), 24-methylene cholesterol (3) and cholesterol (4) were also isolated for the first time from this genus. GLC analysis of the unsaponifiable matter revealed that it contained a high percentage of hydrocarbons (89.474%) with n-hexacosane as a major component (10.979%). Furthermore, the identified sterol represents 7.162%. GLC analysis of the fatty acid methyl esters revealed that nervonic acid is the major fatty acid (73.782%). Compound 3 showed anti-inflammatory activity, while compounds 1 and 5 showed mild anti-oxidant properties.
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