SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE AND 1H-PYRAZOLO[3,4-b]QUINOLINE DERIVATIVES
Amin, M., Ismail, M., Barakat, S., Abdul-Rahman, A., Bayomi, A., El-Gamal, K. (2004). SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE AND 1H-PYRAZOLO[3,4-b]QUINOLINE DERIVATIVES. EKB Journal Management System, 27(2), 237-245. doi: 10.21608/bfsa.2004.65452
Monir A-S. Amin; Mohammed M. Ismail; Saber E-S. Barakat; Ashraf A-A. Abdul-Rahman; Ashraf H. Bayomi; Kamal M.A. El-Gamal. "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE AND 1H-PYRAZOLO[3,4-b]QUINOLINE DERIVATIVES". EKB Journal Management System, 27, 2, 2004, 237-245. doi: 10.21608/bfsa.2004.65452
Amin, M., Ismail, M., Barakat, S., Abdul-Rahman, A., Bayomi, A., El-Gamal, K. (2004). 'SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE AND 1H-PYRAZOLO[3,4-b]QUINOLINE DERIVATIVES', EKB Journal Management System, 27(2), pp. 237-245. doi: 10.21608/bfsa.2004.65452
Amin, M., Ismail, M., Barakat, S., Abdul-Rahman, A., Bayomi, A., El-Gamal, K. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE AND 1H-PYRAZOLO[3,4-b]QUINOLINE DERIVATIVES. EKB Journal Management System, 2004; 27(2): 237-245. doi: 10.21608/bfsa.2004.65452

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW QUINOLINE AND 1H-PYRAZOLO[3,4-b]QUINOLINE DERIVATIVES

Bulletin of Pharmaceutical Sciences Assiut University
Article 6, Volume 27, Issue 2, December 2004, Pages 237-245    PDF (220.49 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2004.65452
Authors
Monir A-S. Amin1; Mohammed M. Ismail2; Saber E-S. Barakat1; Ashraf A-A. Abdul-Rahman1; Ashraf H. Bayomi1; Kamal M.A. El-Gamal1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
2Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Abstract
Vilsmeier formylation of acetanilide I followed by treatment with hydroxylamine produced
2-chloroquinoline-3-carbonitrile II that was condensed with different amines to give 2-
substituted aminoquinolines-3-carbonitriles III. Treatment of II with thiourea yielded 2-
mercaptoquinoline-3-carbonitrile IV, which was converted to its potassium salt V that was
condensed with some chloroacetate esters to produce 2-substituted thioquinoline-3-
carbonitriles VI. Hydrazinolysis of II or IV gave 1H-pyrazolo[3,4-b]quinolin-3-ylamine VII.
Condensation of VII with different aryl aldehydes resulted in the corresponding imines VIII.
Treatment of VII with p-chloro-benzoyl chloride afforded the amide IX. Some of the synthesized
compounds were evaluated for their antibacterial and antifungal activity.
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