Design and synthesis of some thiazolo[3,2-a]benzimidazole quaternary salts of potential antidiabetic | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 2, Volume 24, Issue 1, June 2001, Pages 7-20 PDF (457.15 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2001.65750 | ||
| Authors | ||
| A. A. El-Shorbagi; A. A. Hayallah; N. M. Omar; A. N. Ahmed | ||
| Department of Pharmaceutial Organic Chemistry, Faculty of Pharmacy, University of Assiut, Assiut 71526, Egypt | ||
| Abstract | ||
| The present work reports on the synthesis and preliminary pharmacol. investigation of new 3-aryl-6,7-dimethyl-9-substituted thiazolo[3,2-a]benzimidazolium salts. These derivs. were synthesized by reacting the 3-aryl-6,7-dimethylthiazolo[3,2-a]benzimidazoles with the appropriate quaternizing agent. The latter compds. were, in turn prepd. by cyclodehydration of 5,6-dimethyl-2-(phenacylthio)benzimidazoles in polyphosphoric acid (PPA). The latter derivs. were obtained by the reaction of 5,6-dimethylbenzimidazole-2-thione with the appropriate phenacyl bromide. Some of the tested compds. have shown a pronounced hypoglycemic activity. The results do permit the assignment of compds. having N9-phenacyl entity as promising antidiabetic agents. | ||
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