Release kinetics of aspirin from suppositories | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 3, Volume 23, Issue 1, June 2000, Pages 23-30 PDF (2.06 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2000.65973 | ||
| Authors | ||
| E. A. Fouad* ; F. A. Mohammad | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt | ||
| Abstract | ||
| The release of aspirin from certain suppository bases, mainly oleaginous and water sol., were studied in-vitro by using pH 8 phosphate buffer as the releasing medium. In this study, infant-size suppositories contg. 100 mg aspirin were prepd. and tested by using diffusion cell of 2 compartments sepd. by semipermeable cellophane membrane. After 5 h, 40.6% aspirin was released from Witepsol H15 compared to 24.9% for Suppocire AM. While a base composed of 50% from each of the above formulation showed the lowest release (18.6%). Addn. of 5% Tween 80 enhanced the total aspirin release. Aspirin release from a water-sol. base was 31.7% after 5 h. Salicylic acid resulting from the hydrolysis of aspirin in the diffusion medium was detd. The percent salicylic acid diffused to the total aspirin ranged from 43.7 to 72.6%. Also, the addn. of Tween 80 decreased the salicylic acid released from 59.6 to 43.7%. The results obtained were compared with a com. suppository contg. 130 mg aspirin. A direct relationship was found between the release rate consts. and the dialysis rate consts. | ||
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