PART 1: DESIGN, SYNTHESIS AND EVALUATION OF NEW SITE-SPECIFIC MONOAMINE OXIDASE INHIBITORS | ||
Bulletin of Pharmaceutical Sciences Assiut University | ||
Article 6, Volume 21, Issue 1, June 1998, Pages 41-54 PDF (675.96 K) | ||
Document Type: Original Article | ||
DOI: 10.21608/bfsa.1998.67834 | ||
Authors | ||
F. A. Mohamed1; N. El-Rabbat1; P. Khashaba1; H. H. Farag1; N. Bodor2 | ||
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||
2Center for Drug Discovery, College of Pharmacy, University of Florida, Gainesville, Florida, USA | ||
Abstract | ||
Certain new monoamine oxidase inhibitors (MAOIs) containing a pyridinium moiety as an integral part of their structures (Q) were designed. The quaternaries, their corresponding 1,4-dihydroxypyridine derivatives (CDS) and their parent pyridine compounds (P) were synthesized. A spectrofluorimetric method was used to test their in vitro monoamine oxidase inhibition. The compounds showed reasonable activities by the test performed. | ||
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