THERAPEUTIC EFFICACY OF THYMUS VULGARIS AND MYRISTICA FRAGRANCE HOUTT (NUTMEG) ETHANOLIC EXTRACTAGAINST TOXOPLASMOSIS IN MURINE MODEL | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 9, Volume 49, Issue 1, April 2019, Page 73-79 PDF (443.07 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2019.68288 | ||||
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| Authors | ||||
| TAHANI I. FARAG1; MARWA A. SALAMA1; SAMAH H. YAHIA1; RASHA A. ELFEQY2 | ||||
| 1Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Egypt. | ||||
| 2Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Egypt. | ||||
| Abstract | ||||
| Toxoplasma gondii is a globally obligate intra-cellular protozoan zoonotic disease. This study evaluated the efficacy of Thymus vulgaris and Myristica fragrance Houtt (Nutmeg) ethanolic extracts against chronic toxoplasmosis. A total of fifty laboratory-bred male Swiss Albino mice were infected with Me-49 T. gondii strain and divided into five groups G1:non infected/non-treated control, G2:infected/non-treated, G3: infected/treated with Thymus vulgaris extract, G4: infected/treated with nutmeg extract and G5:infected and treated with Spiramycin. Mice were given Thymus and Myristica ethanolic extract 4 days post infection for 14 days then sacrificed 4 weeks after last dose. Brains and livers were dissected out and processed for histopathological examination. Tissue cyst count evaluated the efficacy of extracts. The results showed that mean number of brain cysts was significantly reduced by 47.5% in mice treated with Thymus extract while Myristica extract treated group showed a mild reduction (0.8%). Thymus effect was near to Spiramycin in cyst reduction (47.5% & 48.89%) respectively. Brain and liver lesions in Thymus treated mice showed considerable improvement. | ||||
| Keywords | ||||
| Egypt; Toxoplasmosis; Thymus vulgaris; Myristica fragrance; ethanolic extracts | ||||
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